A compound with anti-drug resistant bacteria activity having the formula (I):

##STR00001##

is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

The present invention belongs to the technical field of gene therapy, and particularly relates to a series of lipid compounds as well as a lipid carrier, nucleic acid lipid nanoparticle composition and pharmaceutical preparation containing the same. A compound having a structure of a formula (I) provided by the present invention can be used for preparing a lipid carrier together with other lipid compounds, and exhibits pH response, and the entrapment efficiency to a nucleic acid drug is high, which greatly improves in-vivo delivery efficiency of the nucleic acid drug; and furthermore, a lipid compound with a specific structure can be chosen as a lipid carrier based on an organ in which the nucleic acid drug needs to be enriched, having a good market application prospect.

The present invention belongs to the technical field of gene therapy, and particularly relates to a series of lipid compounds as well as a lipid carrier, nucleic acid lipid nanoparticle composition and pharmaceutical preparation containing the same. A compound having a structure of a formula (I) provided by the present invention can be used for preparing a lipid carrier together with other lipid compounds, and exhibits pH response, and the entrapment efficiency to a nucleic acid drug is high, which greatly improves in-vivo delivery efficiency of the nucleic acid drug; and furthermore, a lipid compound with a specific structure can be chosen as a lipid carrier based on an organ in which the nucleic acid drug needs to be enriched, having a good market application prospect.

The present invention relates to semiconducting nanoparticle.

The present invention relates to semiconducting nanoparticle.

The present disclosure relates to the field of synthesis of mercapto compounds, and in particular, to a preparation method of 3-mercaptopropionic acid. The preparation method provided by the present disclosure comprises the steps of: mixing sodium acrylate with sodium hydrosulfide or sodium sulfide for reacting; adding sodium sulfide (or adding sodium sulfide and sulfur powder) for further reacting; crystallizing, and acidifying with an acid to obtain a solution of 3-mercaptopropionic acid. According to the preparation method provided by the present disclosure, the raw materials are inexpensive, the product 3-mercaptopropionic acid can be obtained with a high yield and high purity, moreover, and solid waste and solvent(s) can be separated and recovered; sodium salt can be used as an industrial product after crystallization; the solvent(s) can be recovered and recycled by distillation; and disposal of three wastes is simple.

The present disclosure relates to the field of synthesis of mercapto compounds, and in particular, to a preparation method of 3-mercaptopropionic acid. The preparation method provided by the present disclosure comprises the steps of: mixing sodium acrylate with sodium hydrosulfide or sodium sulfide for reacting; adding sodium sulfide (or adding sodium sulfide and sulfur powder) for further reacting; crystallizing, and acidifying with an acid to obtain a solution of 3-mercaptopropionic acid. According to the preparation method provided by the present disclosure, the raw materials are inexpensive, the product 3-mercaptopropionic acid can be obtained with a high yield and high purity, moreover, and solid waste and solvent(s) can be separated and recovered; sodium salt can be used as an industrial product after crystallization; the solvent(s) can be recovered and recycled by distillation; and disposal of three wastes is simple.

[Problem] To provide a labeled fatty acid derivative for diagnostic imaging that enables the quantification of myocardial fatty acid metabolic activity. [Solution] The inventors, engaging in diligent research into methods that enable the quantification of fatty acid metabolic activity, discovered that a labeled fatty acid derivative represented by formula (1), in which [.sup.18F] has been substituted at a specific position of a long-chain carboxylic acid compound containing a sulfur atom, or a salt thereof, has good accumulation in the myocardium, and enables imaging of fatty acid metabolic activity via positron emission tomography (PET). Therefore, the labeled fatty acid derivative according to the present invention can be used as a radiotracer for swift and noninvasive quantification of myocardial fatty acid metabolic activity, diagnostic imaging of heart diseases such as ischemic heart disease, diagnostic imaging of the therapeutic effects yielded by a heart disease therapeutic agent, and so forth.

[Problem] To provide a labeled fatty acid derivative for diagnostic imaging that enables the quantification of myocardial fatty acid metabolic activity. [Solution] The inventors, engaging in diligent research into methods that enable the quantification of fatty acid metabolic activity, discovered that a labeled fatty acid derivative represented by formula (1), in which [.sup.18F] has been substituted at a specific position of a long-chain carboxylic acid compound containing a sulfur atom, or a salt thereof, has good accumulation in the myocardium, and enables imaging of fatty acid metabolic activity via positron emission tomography (PET). Therefore, the labeled fatty acid derivative according to the present invention can be used as a radiotracer for swift and noninvasive quantification of myocardial fatty acid metabolic activity, diagnostic imaging of heart diseases such as ischemic heart disease, diagnostic imaging of the therapeutic effects yielded by a heart disease therapeutic agent, and so forth.

Aspects of the present disclosure generally relate to functionalized metals, to processes for producing functionalized metals, and to uses of functionalized metals as, e.g., sensing materials for chemiresistive sensors. In an aspect, a process for producing a functionalized metal is provided. The process includes introducing, under first conditions, a first precursor comprising a Group 10 to Group 14 metal with an amine to form a second precursor comprising the Group 10 to Group 14 metal. The process further includes introducing, under second conditions, the second precursor with a third precursor to form the functionalized metal, the third precursor comprising an organic material having the formula HS—R—COOH, wherein R is an unsubstituted hydrocarbyl, a substituted hydrocarbyl, an unsubstituted alkoxy, or a substituted alkoxy.