C07C323/63

N-prop-2-ynyl carboxamide derivatives and their use as TRPA1 antagonists

Compounds of formula I, wherein A, B, X, Z and R.sub.1-R.sub.6, are as defined in the claims, exhibit TRPA 1 activity and are thus useful as TRPA1 modulators. ##STR00001##

N-prop-2-ynyl carboxamide derivatives and their use as TRPA1 antagonists

Compounds of formula I, wherein A, B, X, Z and R.sub.1-R.sub.6, are as defined in the claims, exhibit TRPA 1 activity and are thus useful as TRPA1 modulators. ##STR00001##