The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or relapsing infections. Pharmaceutical compositions, methods of treating diseases (e.g., bacterial infections), and methods of reducing bacterial virulence are also provided.

Disclosed herein are embodiments of an extractant that can be used for chromatographic isolation of radioisotopes and/or metal species. The extractant can be combined with a support medium to provide an extractant composition that selectively and efficiently binds particular radioisotopes and/or metal species. Also disclosed herein are embodiments of a method for using the disclosed extractant embodiments, as well as embodiments of a method for making the extractant and extractant composition.

Disclosed herein are embodiments of an extractant that can be used for chromatographic isolation of radioisotopes and/or metal species. The extractant can be combined with a support medium to provide an extractant composition that selectively and efficiently binds particular radioisotopes and/or metal species. Also disclosed herein are embodiments of a method for using the disclosed extractant embodiments, as well as embodiments of a method for making the extractant and extractant composition.

The present invention relates the compounds of the formula I

##STR00001##

and their N-oxides and agriculturally acceptable salts thereof, and their use for combating phytopathogenic harmful fungi, wherein the variables are defined as given in the description and claims. Further the present invention relates to novel mixtures comprising at least one such compound of the formula I and at least one further pesticidally active substance selected from the group consisting of herbicides, safeners, fungicides, insecticides, and plant growth regulators; and to agrochemical compositions comprising at least one such compound of the formula I and to agrochemical compositions further comprising seeds.

Provided herein are compositions and methods for generating polypeptides using non-natural amino acids (nnAAs) and genetic machinery, wherein the modified polypeptides, such as therapeutic polypeptides, bind to albumin, such as serum albumin. Methods of substituting a non-natural amino acid in a first polypeptide to obtain a modified polypeptide, the nnAA in some instances comprising an albumin targeting group, are disclosed, as are methods for making populations of such modified polypeptides. A therapeutic polypeptide, interleukin-1 receptor antagonist (IL-1RA) is exemplified using the disclosed methods.

Provided herein are compositions and methods for generating polypeptides using non-natural amino acids (nnAAs) and genetic machinery, wherein the modified polypeptides, such as therapeutic polypeptides, bind to albumin, such as serum albumin. Methods of substituting a non-natural amino acid in a first polypeptide to obtain a modified polypeptide, the nnAA in some instances comprising an albumin targeting group, are disclosed, as are methods for making populations of such modified polypeptides. A therapeutic polypeptide, interleukin-1 receptor antagonist (IL-1RA) is exemplified using the disclosed methods.

An object of the present invention is to provide a benzylamide compound or a salt thereof that controls a mite. The present invention provides a benzylamide compound represented by Formula (1): or a salt thereof, wherein R.sup.1 represents C.sub.1-6 alkyl or C.sub.1-6 haloalkyl; R.sup.2 and R.sup.3 are identical or different and each represent hydrogen, halogen, cyano, nitro, C.sub.1-6 alkyl, or the like; R.sup.4 represents hydrogen, formyl C.sub.1-6 alkyl, or the like; R.sup.5 and R.sup.6 are identical or different and each represent hydrogen, halogen, or C.sub.1-6 alkyl, or the like; R.sup.7, R.sup.8, R.sup.9, R.sup.10, and R.sup.11 are identical or different and each represent hydrogen, halogen, or the like; X represents oxygen or sulfur; and n represents an integer of 0 to 2.

##STR00001##

An object of the present invention is to provide a benzylamide compound or a salt thereof that controls a mite. The present invention provides a benzylamide compound represented by Formula (1): or a salt thereof, wherein R.sup.1 represents C.sub.1-6 alkyl or C.sub.1-6 haloalkyl; R.sup.2 and R.sup.3 are identical or different and each represent hydrogen, halogen, cyano, nitro, C.sub.1-6 alkyl, or the like; R.sup.4 represents hydrogen, formyl C.sub.1-6 alkyl, or the like; R.sup.5 and R.sup.6 are identical or different and each represent hydrogen, halogen, or C.sub.1-6 alkyl, or the like; R.sup.7, R.sup.8, R.sup.9, R.sup.10, and R.sup.11 are identical or different and each represent hydrogen, halogen, or the like; X represents oxygen or sulfur; and n represents an integer of 0 to 2.

##STR00001##

Process for converting a carboxamide to a thiocarboxamide includes reacting (a) a substrate that comprises a heteroatom-containing moiety and a carboxamide moiety with (b) a dialkyl dithiophosphate and/or a salt thereof. The heteroatom-containing moiety includes a heteroatom selected from the group consisting of N, O, and S. Processes for preparing piperidine-4-thiocarboxamide are described.

Process for converting a carboxamide to a thiocarboxamide includes reacting (a) a substrate that comprises a heteroatom-containing moiety and a carboxamide moiety with (b) a dialkyl dithiophosphate and/or a salt thereof. The heteroatom-containing moiety includes a heteroatom selected from the group consisting of N, O, and S. Processes for preparing piperidine-4-thiocarboxamide are described.