Patent classifications
C07C327/42
PHENOXY-ACETYL-THIOUREIDO-BENZENESULFONAMIDE DERIVATIVES, AND THEIR USES
A compound of formula I:
##STR00001##
wherein A is NH or CH.sub.2; G.sub.1 is a linear or a cyclic alkyl; Y.sub.1 is CH or N; Y.sub.2 is O, N or CH, W is O, N or CH; Z is NH or O; X.sub.1 and X.sub.2 and R, and R1 to R8 are functional groups. Also, a method of treating a viral infection or pathology linked to a viral infection in which an effective amount of the compound is administered to a patient in need thereof.
PHENOXY-ACETYL-THIOUREIDO-BENZENESULFONAMIDE DERIVATIVES, AND THEIR USES
A compound of formula I:
##STR00001##
wherein A is NH or CH.sub.2; G.sub.1 is a linear or a cyclic alkyl; Y.sub.1 is CH or N; Y.sub.2 is O, N or CH, W is O, N or CH; Z is NH or O; X.sub.1 and X.sub.2 and R, and R1 to R8 are functional groups. Also, a method of treating a viral infection or pathology linked to a viral infection in which an effective amount of the compound is administered to a patient in need thereof.
FUNCTIONALLY MODIFIED POLYPEPTIDES AND RADIOBIOSYNTHESIS
Provided herein are compositions and methods for generating polypeptides using non-natural amino acids (nnAAs) and genetic machinery, wherein the modified polypeptides, such as therapeutic polypeptides, bind to albumin, such as serum albumin. Methods of substituting a non-natural amino acid in a first polypeptide to obtain a modified polypeptide, the nnAA in some instances comprising an albumin targeting group, are disclosed, as are methods for making populations of such modified polypeptides. A therapeutic polypeptide, interleukin-1 receptor antagonist (IL-1RA) is exemplified using the disclosed methods.
FUNCTIONALLY MODIFIED POLYPEPTIDES AND RADIOBIOSYNTHESIS
Provided herein are compositions and methods for generating polypeptides using non-natural amino acids (nnAAs) and genetic machinery, wherein the modified polypeptides, such as therapeutic polypeptides, bind to albumin, such as serum albumin. Methods of substituting a non-natural amino acid in a first polypeptide to obtain a modified polypeptide, the nnAA in some instances comprising an albumin targeting group, are disclosed, as are methods for making populations of such modified polypeptides. A therapeutic polypeptide, interleukin-1 receptor antagonist (IL-1RA) is exemplified using the disclosed methods.
MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).
##STR00001##
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
This document discloses molecules having the following formula (Formula One):
##STR00001##
and processes associated therewith.
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
This document discloses molecules having the following formula (Formula One):
##STR00001##
and processes associated therewith.
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
This document discloses molecules having the following formula (Formula One):
##STR00001##
and processes associated therewith.
Pesticidal compositions and processes related thereto
This document discloses molecules having the following formula (Formula One): ##STR00001##
and processes associated therewith.
Pesticidal compositions and processes related thereto
This document discloses molecules having the following formula (Formula One): ##STR00001##
and processes associated therewith.