Patent classifications
C07C329/06
CATIONIC LIPID COMPOUND, PREPARATION METHOD AND USE THEREOF, AND DELIVERY SYSTEM FOR mRNA
A cationic lipid compound, a preparation method and a use thereof, and a delivery system for mRNA are provided. The cationic lipid compound has a structure represented by formula (I):
##STR00001##
In formula (I): X is O or N; n is 2-4; m is 2-4; a is 0 or 1; R.sub.1 is a chain structure comprising a tertiary amine; R.sub.2 is a linear fatty acyl group or a branched chain fatty acyl group; R.sub.3 is a branched chain fatty acyl group. The cationic lipid compound is used for preparing a delivery system for mRNA.
CATIONIC LIPID COMPOUND, PREPARATION METHOD AND USE THEREOF, AND DELIVERY SYSTEM FOR mRNA
A cationic lipid compound, a preparation method and a use thereof, and a delivery system for mRNA are provided. The cationic lipid compound has a structure represented by formula (I):
##STR00001##
In formula (I): X is O or N; n is 2-4; m is 2-4; a is 0 or 1; R.sub.1 is a chain structure comprising a tertiary amine; R.sub.2 is a linear fatty acyl group or a branched chain fatty acyl group; R.sub.3 is a branched chain fatty acyl group. The cationic lipid compound is used for preparing a delivery system for mRNA.
Analogs of pterostilbene amino acid bearing carbonates for treating a non-alcoholic fatty liver disease and nonalcoholic steatohepatitis
A series of novel analogs of water soluble pterostilbene amino acid bearing carbonates were synthesized, which show activities in treating a non-alcoholic fatty liver disease and a nonalcoholic steatohepatitis (NASH).
PROCESS FOR PREPARING MODULATORS OF EUKARYOTIC INITIATION FACTOR 2B
The present disclosure relates generally to methods for the preparation of Compound (I-1): I-1 or a stereoisomer or mixture of stereoisomers thereof, or salt of each thereof, as well as compounds and salts which are useful in the synthesis thereof.
##STR00001##
PROCESS FOR PREPARING MODULATORS OF EUKARYOTIC INITIATION FACTOR 2B
The present disclosure relates generally to methods for the preparation of Compound (I-1): I-1 or a stereoisomer or mixture of stereoisomers thereof, or salt of each thereof, as well as compounds and salts which are useful in the synthesis thereof.
##STR00001##
THIOCARBONATE COMPOSITIONS FOR LITHIUM-SULFUR BATTERIES
The present disclosure provides compounds useful as electrolyte materials, and lithium sulfur batteries comprising the same.
THIOCARBONATE COMPOSITIONS FOR LITHIUM-SULFUR BATTERIES
The present disclosure provides compounds useful as electrolyte materials, and lithium sulfur batteries comprising the same.