C07C329/06

CATIONIC LIPID COMPOUND, PREPARATION METHOD AND USE THEREOF, AND DELIVERY SYSTEM FOR mRNA

A cationic lipid compound, a preparation method and a use thereof, and a delivery system for mRNA are provided. The cationic lipid compound has a structure represented by formula (I):

##STR00001##

In formula (I): X is O or N; n is 2-4; m is 2-4; a is 0 or 1; R.sub.1 is a chain structure comprising a tertiary amine; R.sub.2 is a linear fatty acyl group or a branched chain fatty acyl group; R.sub.3 is a branched chain fatty acyl group. The cationic lipid compound is used for preparing a delivery system for mRNA.

CATIONIC LIPID COMPOUND, PREPARATION METHOD AND USE THEREOF, AND DELIVERY SYSTEM FOR mRNA

A cationic lipid compound, a preparation method and a use thereof, and a delivery system for mRNA are provided. The cationic lipid compound has a structure represented by formula (I):

##STR00001##

In formula (I): X is O or N; n is 2-4; m is 2-4; a is 0 or 1; R.sub.1 is a chain structure comprising a tertiary amine; R.sub.2 is a linear fatty acyl group or a branched chain fatty acyl group; R.sub.3 is a branched chain fatty acyl group. The cationic lipid compound is used for preparing a delivery system for mRNA.

Analogs of pterostilbene amino acid bearing carbonates for treating a non-alcoholic fatty liver disease and nonalcoholic steatohepatitis

A series of novel analogs of water soluble pterostilbene amino acid bearing carbonates were synthesized, which show activities in treating a non-alcoholic fatty liver disease and a nonalcoholic steatohepatitis (NASH).

PROCESS FOR PREPARING MODULATORS OF EUKARYOTIC INITIATION FACTOR 2B
20250376432 · 2025-12-11 ·

The present disclosure relates generally to methods for the preparation of Compound (I-1): I-1 or a stereoisomer or mixture of stereoisomers thereof, or salt of each thereof, as well as compounds and salts which are useful in the synthesis thereof.

##STR00001##

PROCESS FOR PREPARING MODULATORS OF EUKARYOTIC INITIATION FACTOR 2B
20250376432 · 2025-12-11 ·

The present disclosure relates generally to methods for the preparation of Compound (I-1): I-1 or a stereoisomer or mixture of stereoisomers thereof, or salt of each thereof, as well as compounds and salts which are useful in the synthesis thereof.

##STR00001##

THIOCARBONATE COMPOSITIONS FOR LITHIUM-SULFUR BATTERIES
20250391914 · 2025-12-25 ·

The present disclosure provides compounds useful as electrolyte materials, and lithium sulfur batteries comprising the same.

THIOCARBONATE COMPOSITIONS FOR LITHIUM-SULFUR BATTERIES
20250391914 · 2025-12-25 ·

The present disclosure provides compounds useful as electrolyte materials, and lithium sulfur batteries comprising the same.