The present invention relates to an organic compound that can enhance the light efficiency of light extracted to the outside of an organic light-emitting element due to having a low refractive index, and thus can be effectively utilized as a material for a light efficiency improving layer provided in the organic light-emitting element. The compound according to the present invention can be employed in the light efficiency improving layer to achieve a high-efficiency, long-lifespan organic light-emitting element having improved light-emitting efficiency, color purity, and lifespan characteristics, as well as low-voltage driving characteristics, and thus can be effectively used in various lighting and display elements.

The present invention relates to an organic compound that can enhance the light efficiency of light extracted to the outside of an organic light-emitting element due to having a low refractive index, and thus can be effectively utilized as a material for a light efficiency improving layer provided in the organic light-emitting element. The compound according to the present invention can be employed in the light efficiency improving layer to achieve a high-efficiency, long-lifespan organic light-emitting element having improved light-emitting efficiency, color purity, and lifespan characteristics, as well as low-voltage driving characteristics, and thus can be effectively used in various lighting and display elements.

The invention discloses a novel compound of Formula (I) or a pharmaceutically acceptable salt thereof that binds tightly to a hydrophobic binding pocket of MM, preventing binding of Mdm2 to the tumour suppressor p53 and increasing p53 levels. It further discloses the use of the compound or a pharmaceutically acceptable salt thereof to treat Mdm2 cancers and its use in the manufacture of a medicament.

The invention discloses a novel compound of Formula (I) or a pharmaceutically acceptable salt thereof that binds tightly to a hydrophobic binding pocket of MM, preventing binding of Mdm2 to the tumour suppressor p53 and increasing p53 levels. It further discloses the use of the compound or a pharmaceutically acceptable salt thereof to treat Mdm2 cancers and its use in the manufacture of a medicament.

The invention relates to compounds of formula (I), and their use as herbicides. In said formula, R.sup.1 to R.sup.9 represent groups such as hydrogen, halo-gen or organic groups such as alkyl, alkenyl, alkynyl, or alkoxy; X is a bond or a divalent unit; Y is hydrogen, cyano, hydroxyl or a linear or cyclic organic group. The invention further refers to a composition comprising such compound and to the use thereof for controlling unwanted vegetation.

##STR00001##

The invention relates to compounds of formula (I), and their use as herbicides. In said formula, R.sup.1 to R.sup.9 represent groups such as hydrogen, halo-gen or organic groups such as alkyl, alkenyl, alkynyl, or alkoxy; X is a bond or a divalent unit; Y is hydrogen, cyano, hydroxyl or a linear or cyclic organic group. The invention further refers to a composition comprising such compound and to the use thereof for controlling unwanted vegetation.

##STR00001##

Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein:

##STR00001##

or a pharmaceutically acceptable salt thereof.

Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein:

##STR00001##

or a pharmaceutically acceptable salt thereof.

The present invention provides compounds and compositions that inhibit Factor XIa or kallikrein and methods of using these compounds and composition.

The present invention provides compounds and compositions that inhibit Factor XIa or kallikrein and methods of using these compounds and composition.