Disclosed are compounds of formula I, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising a compound of formula I, and methods involving use of the compounds and compositions in the treatment and prevention of diseases and conditions characterized by aberrant complement system activity.

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The present invention relates to a compound as represented by formula (I). The present invention also provides compositions and formulations containing such compounds, and methods for using and preparing such compounds.

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The present invention relates to a compound as represented by formula (I). The present invention also provides compositions and formulations containing such compounds, and methods for using and preparing such compounds.

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Provided herein, inter alia, are methods and compounds for inhibiting K-Ras and for treating cancer.

A shielding cover and a display device are provided. The shielding cover includes: a shielding cover body; and a shielding cover accessory fixedly connected to the shielding cover body. The shielding cover accessory includes: an accessory bottom including a flat bottom; a connecting arm through which the shielding cover accessory is connected to the shielding cover body; and a positioning arm. The connecting arm and the positioning arm are connected to two opposite ends of the accessory bottom, and protrude in opposite directions from the accessory bottom. The shielding cover accessory further includes a plurality of card slots arranged at positions of the flat bottom close to the positioning arm, each card slot penetrates the flat bottom in a direction perpendicular to the flat bottom, and the plurality of card slots are arranged at intervals in a direction parallel to an extending direction of the positioning arm.

Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.

Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.

Indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).

Indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).

Disclosed herein are compounds of the formula

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as well as methods for their use in treating neurologic and brain disorders.