The present invention relates to compounds useful as CCR9 modulators, to compositions containing them, to methods of making them, and to methods of using them. In particular, the present invention relates to compounds capable of modulating the function of the CCR9 receptor by acting as partial agonists, antagonists or inverse agonists. Such compounds may be useful to treat, prevent or ameliorate a disease or condition associated with CCR9 activation, including inflammatory and immune disorder diseases or conditions such as inflammatory bowel diseases (IBD).

The present invention relates to compounds useful as CCR9 modulators, to compositions containing them, to methods of making them, and to methods of using them. In particular, the present invention relates to compounds capable of modulating the function of the CCR9 receptor by acting as partial agonists, antagonists or inverse agonists. Such compounds may be useful to treat, prevent or ameliorate a disease or condition associated with CCR9 activation, including inflammatory and immune disorder diseases or conditions such as inflammatory bowel diseases (IBD).

An organic compound, a light modulating composition and a light modulating device are provided. The organic compound has a chemical structure represented by formula (I):
XArX(I) wherein X is ##STR00001##
Ar is ##STR00002##
The organic compound is transparent in its neutral state. The amide group or imide group introduced into the aromatic amine not only enhances the solubility of the organic compound in the solvent, but also enhances the electrochemical stability of the organic compound.

An organic compound, a light modulating composition and a light modulating device are provided. The organic compound has a chemical structure represented by formula (I):
XArX(I) wherein X is ##STR00001##
Ar is ##STR00002##
The organic compound is transparent in its neutral state. The amide group or imide group introduced into the aromatic amine not only enhances the solubility of the organic compound in the solvent, but also enhances the electrochemical stability of the organic compound.

The present invention relates to compounds useful as CCR9 modulators, to compositions containing them, to methods of making them, and to methods of using them. In particular, the present invention relates to compounds capable of modulating the function of the CCR9 receptor by acting as partial agonists, antagonists or inverse agonists. Such compounds may be useful to treat, prevent or ameliorate a disease or condition associated with CCR9 activation, including inflammatory and immune disorder diseases or conditions such as inflammatory bowel diseases (IBD). ##STR00001##

The present invention relates to compounds useful as CCR9 modulators, to compositions containing them, to methods of making them, and to methods of using them. In particular, the present invention relates to compounds capable of modulating the function of the CCR9 receptor by acting as partial agonists, antagonists or inverse agonists. Such compounds may be useful to treat, prevent or ameliorate a disease or condition associated with CCR9 activation, including inflammatory and immune disorder diseases or conditions such as inflammatory bowel diseases (IBD). ##STR00001##

One-pot synthesis methods for producing amines from activated allenes and derivatives thereof are provided, as well as the compounds produced thereby.

One-pot synthesis methods for producing amines from activated allenes and derivatives thereof are provided, as well as the compounds produced thereby.

The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, ##STR00001## where in the formula the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q stands for a hydroxyl-group and Z stands for a hydroxyl- or oxo-group, R.sup.1 and R.sup.2 independently represent hydrogen atom or a straight or branched C.sub.1-10 alkyl- or aralkyl-group, optionally substituted with ONO.sub.2 group, or an aralkyl- or aryl-group, which contains heteroatom, R.sup.3 represents a straight or branched, saturated or unsaturated C.sub.4-6 hydrocarbon group, or a C.sub.4-10 alkylcycloalkyl- or cycloalkyl-group, or an optionally with alkyl group or halogen atom substituted phenyl-, C.sub.7-10 alkylaryl- or hetaryl-group, Y represents (CH.sub.2).sub.n group or O atom or S atom, and where n=0-3.

The invention relates to cross-linkable thermoplastics, processes of making such cross-linkable thermoplastics and products comprising such cross-linkable thermoplastics. Such cross-linkable thermoplastics provide articles made by the additive manufacturing (AM) process with increased strength, the desired in use temperature stability and the desired thermo-oxidative stability.