The present disclosure relates to a plurality of host materials and an organic electroluminescent device comprising the same. By comprising the specific combination of compounds according to the present disclosure as a plurality of host materials according to the present disclosure, it is possible to provide an organic electroluminescent device having improved driving voltage, luminous efficiency, and/or lifetime property compared to the conventional organic electroluminescent devices.

The present disclosure relates to a plurality of host materials and an organic electroluminescent device comprising the same. By comprising the specific combination of compounds according to the present disclosure as a plurality of host materials according to the present disclosure, it is possible to provide an organic electroluminescent device having improved driving voltage, luminous efficiency, and/or lifetime property compared to the conventional organic electroluminescent devices.

Provided are methods of treatment of eosinophilic GI diseases comprising prescribing and/or administering to an individual in need thereof a standard dose of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid (Compound 1), or a pharmaceutically acceptable salt thereof.

A compound is represented by a formula (1) below, in which k is an integer of 0 or more, m is an integer of 1 or more, n is an integer of 2 or more. L is a substituted or unsubstituted aromatic hydrocarbon ring having 6 to 30 ring carbon atoms, CN is a cyano group, and D.sub.1 and D.sub.2 are each independently represented by one of a formula (2), a formula (3) and formula (3x) below, D.sub.1 and D.sub.2 being optionally mutually the same or different.

##STR00001##

A compound is represented by a formula (1) below, in which k is an integer of 0 or more, m is an integer of 1 or more, n is an integer of 2 or more. L is a substituted or unsubstituted aromatic hydrocarbon ring having 6 to 30 ring carbon atoms, CN is a cyano group, and D.sub.1 and D.sub.2 are each independently represented by one of a formula (2), a formula (3) and formula (3x) below, D.sub.1 and D.sub.2 being optionally mutually the same or different.

##STR00001##

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods that restore DNA binding affinity of p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. The organic electroluminescent device having a low driving voltage and/or a high luminous efficiency and/or a long lifespan can be provided, by comprising an organic electroluminescent compound according to the present disclosure.

The present invention is directed to methods of treating hematological cancers, such as acute myleiod leukemia, with tetracyclines, or a pharmaceutically acceptable salt thereof.

A compound is represented by one of formulae (11) to (13). R.sub.1 to R.sub.4 each independently represent a group represented by a formula (1-1) or the like, or a group represented by a formula (2-1), a group represented by a formula (2-2) or the like. At least one of R.sub.1 to R.sub.4 is the group represented by the formula (1-1) or the like. At least one of R.sub.1 to R.sub.4 is the group represented by the formula (2-1), (2-2) or the like. For instance, X.sub.1 represents an oxygen atom, a sulfur atom, or CR.sub.151R.sub.152, R.sub.101 to R.sub.110 and R.sub.151 and R.sub.152 each independently representing a hydrogen atom or a substituent. For instance, R.sub.161 to R.sub.168 and R.sub.171 and R.sub.180 each independently represent a hydrogen atom or a substituent. * each independently represents a bonding position to a carbon atom in a benzene ring in each of formulae (11) to (13): ##STR00001##

A compound is represented by one of formulae (11) to (13). R.sub.1 to R.sub.4 each independently represent a group represented by a formula (1-1) or the like, or a group represented by a formula (2-1), a group represented by a formula (2-2) or the like. At least one of R.sub.1 to R.sub.4 is the group represented by the formula (1-1) or the like. At least one of R.sub.1 to R.sub.4 is the group represented by the formula (2-1), (2-2) or the like. For instance, X.sub.1 represents an oxygen atom, a sulfur atom, or CR.sub.151R.sub.152, R.sub.101 to R.sub.110 and R.sub.151 and R.sub.152 each independently representing a hydrogen atom or a substituent. For instance, R.sub.161 to R.sub.168 and R.sub.171 and R.sub.180 each independently represent a hydrogen atom or a substituent. * each independently represents a bonding position to a carbon atom in a benzene ring in each of formulae (11) to (13): ##STR00001##