C07D213/24

USE OF BISPYRIDINES TO IMPROVE LABELING OF NUCLEOPHILES
20190041384 · 2019-02-07 ·

Bispyridines improve the labeling of nucleophiles, including amines and thiols and are particularly useful for improving labeling with acidic and basic labels. Use of bispyridines with such labels dramatically increases labeling compared to protocols without a bispyridine. The labeled nucleophile can then be subjected to standard analytical methods.

USE OF BISPYRIDINES TO IMPROVE LABELING OF NUCLEOPHILES
20190041384 · 2019-02-07 ·

Bispyridines improve the labeling of nucleophiles, including amines and thiols and are particularly useful for improving labeling with acidic and basic labels. Use of bispyridines with such labels dramatically increases labeling compared to protocols without a bispyridine. The labeled nucleophile can then be subjected to standard analytical methods.

Alkynyl-tolanes, liquid-crystal mixtures containing them and components for high-frequency technology

Compounds of formula I ##STR00001##
their use in liquid-crystalline media, for example, for the phase shifting of microwaves for tunable phased-array antennae, and their use for high-frequency components, in particular antennae, especially for the gigahertz range.

Alkynyl-tolanes, liquid-crystal mixtures containing them and components for high-frequency technology

Compounds of formula I ##STR00001##
their use in liquid-crystalline media, for example, for the phase shifting of microwaves for tunable phased-array antennae, and their use for high-frequency components, in particular antennae, especially for the gigahertz range.

METHOD OF TREATING OR PREVENTING RAS-MEDIATED DISEASES
20180251443 · 2018-09-06 ·

Disclosed are compounds, for example, a compound of formula I, wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.

##STR00001##

METHOD OF TREATING OR PREVENTING RAS-MEDIATED DISEASES
20180251443 · 2018-09-06 ·

Disclosed are compounds, for example, a compound of formula I, wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.

##STR00001##

INDENYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF
20180208573 · 2018-07-26 ·

Disclosed are compounds, for example, compounds of formula (I), (Formula (I) wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.

##STR00001##

INDENYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF
20180208573 · 2018-07-26 ·

Disclosed are compounds, for example, compounds of formula (I), (Formula (I) wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.

##STR00001##

Combustion boiler with pre-drying fuel chute
09964303 · 2018-05-08 ·

A solid fuel boiler with one or more fuel chutes configured to pre-dry wet solid fuel prior to loading into a combustion chamber of the boiler, enabling higher thermal efficiencies and burning less fuel to produce the same steam quantity. The pre-drying fuel chutes pass through the boiler where hot combustion gases radiantly and convectivelyheat the chute walls to dry the wet solid fuel by radiant, convective, and/or conductive heating. Agitator mechanisms or structures within the chute mix the fuel for uniform heating, break up clumps of wet fuel, regulate the speed of falling fuel, prevent sticking, dry the fuel by means of steam and/or hot air, transport and deliver a cooling medium while a chute is offline in an operating boiler, and suppress fire using steam injection. Fuel from the chute can flow into a fuel storage bin or directly into the combustion zone of the furnace.

IRIDIUM COMPLEX COMPOUND, COMPOSITION FOR ORGANIC ELECTROLUMINESCENT ELEMENT, ORGANIC ELECTROLUMINESCENT ELEMENT, METHOD FOR PRODUCING SAME, AND DISPLAY DEVICE

An iridium complex compound represented by formula (1) below.

##STR00001## R.sup.2 to R.sup.5 are each selected from a [substituent group W]; R.sup.1, R.sup.6 to R.sup.10, and R.sup.14 are a hydrogen atom, F, a methyl group, a trifluoromethyl group, an ethyl group, a vinyl group, or an ethynyl group; R.sup.15 and R.sup.16 are a linear, branched, or cyclic alkyl group having 1 to 30 carbon atoms, an aralkyl group having 5 to 60 carbon atoms, or a heteroaralkyl group having 5 to 60 carbon atoms; one of R.sup.11 to R.sup.13 has a structure represented by formula (2) below; and the remaining two are selected from a [substituent group Z].

##STR00002##