Patent classifications
C07D215/20
7- OR 8-HYDROXY-ISOQUINOLINE AND 7- OR 8-HYDROXY-QUINOLINE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD)
- Simon Giroux ,
- Michael Philip CLARK ,
- Michael Aaron Brodney ,
- Peter Jones ,
- Michael Paul DENINNO ,
- Wenxin Gu ,
- Qing TANG ,
- Steven David STONE ,
- Timothy J. Senter ,
- Zachary GALE-DAY ,
- Diane Marie BOUCHER ,
- Lev T.D. FANNING ,
- Amy B. HALL ,
- Dennis James HURLEY ,
- Mac Arthur Johnson, Jr. ,
- John Patrick Maxwell ,
- Rebecca Jane SWETT ,
- Timothy Lewis TAPLEY ,
- Stephen A. THOMSON ,
- Veronique DAMAGNEZ ,
- Kevin Michael Cottrell
7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).
Toll-like receptor 8 (TLR8) specific antagonists and methods of making and uses thereof
Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.
Toll-like receptor 8 (TLR8) specific antagonists and methods of making and uses thereof
Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.
SELECTIVE NON-CYCLIC NUCLEOTIDE ACTIVATORS FOR THE CAMP SENSOR EPAC1
The invention relates generally to novel EPAC1 activators, such as Formula I and II and the preparation thereof as well as the use of EPAC1 activators disclosed herein as to selectively activate EPAC1 in cells.
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SELECTIVE NON-CYCLIC NUCLEOTIDE ACTIVATORS FOR THE CAMP SENSOR EPAC1
The invention relates generally to novel EPAC1 activators, such as Formula I and II and the preparation thereof as well as the use of EPAC1 activators disclosed herein as to selectively activate EPAC1 in cells.
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QUINOLINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE
The present invention provides novel compounds having the general formula: wherein R.sup.1 to R.sup.11 are as described herein, compositions including the compounds and methods of using the compounds.
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QUINOLINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE
The present invention provides novel compounds having the general formula: wherein R.sup.1 to R.sup.11 are as described herein, compositions including the compounds and methods of using the compounds.
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AZABICYCLIC(THIO)AMIDES AS FUNGICIDAL COMPOUNDS
The present invention relates to azabicyclic (thio)amide compounds and the uses thereof for controlling phytopathogenic microorganisms such as phytopathogenic fungi. It also relates to processes and intermediates for preparing these compounds
AZABICYCLIC(THIO)AMIDES AS FUNGICIDAL COMPOUNDS
The present invention relates to azabicyclic (thio)amide compounds and the uses thereof for controlling phytopathogenic microorganisms such as phytopathogenic fungi. It also relates to processes and intermediates for preparing these compounds
Processes for the Preparation of a Kinase Inhibitor
The present invention relates to processes for the synthetic preparation of c-Met inhibitors of Formula I, or pharmaceutically acceptable salts thereof. The present invention further relates to processes for the synthetic preparation of the c-Met inhibitor, Compound 1, or a pharmaceutically acceptable salt thereof. The present invention also relates to processes for the synthetic preparation of Compound 1.hemifumarate. The invention further relates to large scale processes for the synthetic preparation of the c-Met inhibitor, Compound 1 and Compound 1.hemifumarate.