Patent classifications
C07D215/48
Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT)
The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I) ##STR00001##
Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT)
The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I) ##STR00001##
2,3-disubstituted 1-acyl-4-amino-1,2,3,4-tetrahydroquinoline derivatives and their use as bromodomain inhibitors
The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.
2,3-disubstituted 1-acyl-4-amino-1,2,3,4-tetrahydroquinoline derivatives and their use as bromodomain inhibitors
The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.
15-PGDH INHIBITOR
[Problem]
To provide a compound having a 15-PGDH inhibitory effect.
[Solution]
A compound represented by general formula (1) or a pharmacologically acceptable salt thereof.
[1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors
Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder. ##STR00001##
[1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors
Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder. ##STR00001##
HETEROCYCLIC COMPOUNDS AND USES THEREOF
Provided herein are novel heterocyclic compounds, for example, compounds having Formula I, I-P, II, II-P, or III. Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH).
##STR00001##
Crystal form of lenvatinib mesylate and preparation method therefor
A new crystal form of lenvatinib mesylate, a preparation method thereof and a use thereof in the preparation of a drug for treating cancer.
Crystal form of lenvatinib mesylate and preparation method therefor
A new crystal form of lenvatinib mesylate, a preparation method thereof and a use thereof in the preparation of a drug for treating cancer.