The embodiments of the present invention provide processes and intermediates for the preparation of D1 PAM I: Formula (I).

##STR00001##

The embodiments of the present invention provide processes and intermediates for the preparation of D1 PAM I: Formula (I).

##STR00001##

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

The present invention provides compounds having formula (I):

##STR00001##

and pharmaceutically acceptable derivatives thereof, wherein R.sub.1-R.sub.4, n, p, A, B, D, E, L and AR.sub.1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).

The present invention provides compounds having formula (I):

##STR00001##

and pharmaceutically acceptable derivatives thereof, wherein R.sub.1-R.sub.4, n, p, A, B, D, E, L and AR.sub.1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).

The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below: ##STR00001##

The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below: ##STR00001##

A compound of formula Ia, Ib, Ic or Id: ##STR00001##
wherein: n is 1 or 2; R.sup.N is H or Me; R.sup.1 is optionally one or more halo or methyl groups; R.sup.2a and R.sup.2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH.sub.2OH; R.sup.2c and R.sup.2d (if present) are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH.sub.2OH; R.sup.3a and R.sup.3b are independently selected from H and Me; R.sup.4a is selected from OH, —NH.sub.2, —C(═O)NH.sub.2, and —CH.sub.2OH; R.sup.4b is either H or Me; R.sup.5 is either H or Me; m is 1 or 2; q is 0 or 1; R.sup.11a, R.sup.11b, R.sup.11c and R.sup.11d are independently selected from H, halo, C.sub.1-4 alkyl, C.sub.1-4 fluoroalkyl, C.sub.3-4 cycloalkyl, C.sub.1-4 alkyloxy, NH—C.sub.1-4 alkyl and cyano; R.sup.12a and R.sup.12b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH.sub.2OH; R.sup.12c and R.sup.12d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH.sub.2OH; R.sup.12e is H or Me; R.sup.13a and R.sup.13b are independently selected from H and Me; R.sup.14 is either H or Me; R.sup.16a and R.sup.16b are independently selected from H and Me; R.sup.6 is selected from H, OMe, and OEt.

A compound of formula Ia, Ib, Ic or Id: ##STR00001##
wherein: n is 1 or 2; R.sup.N is H or Me; R.sup.1 is optionally one or more halo or methyl groups; R.sup.2a and R.sup.2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH.sub.2OH; R.sup.2c and R.sup.2d (if present) are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH.sub.2OH; R.sup.3a and R.sup.3b are independently selected from H and Me; R.sup.4a is selected from OH, —NH.sub.2, —C(═O)NH.sub.2, and —CH.sub.2OH; R.sup.4b is either H or Me; R.sup.5 is either H or Me; m is 1 or 2; q is 0 or 1; R.sup.11a, R.sup.11b, R.sup.11c and R.sup.11d are independently selected from H, halo, C.sub.1-4 alkyl, C.sub.1-4 fluoroalkyl, C.sub.3-4 cycloalkyl, C.sub.1-4 alkyloxy, NH—C.sub.1-4 alkyl and cyano; R.sup.12a and R.sup.12b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH.sub.2OH; R.sup.12c and R.sup.12d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH.sub.2OH; R.sup.12e is H or Me; R.sup.13a and R.sup.13b are independently selected from H and Me; R.sup.14 is either H or Me; R.sup.16a and R.sup.16b are independently selected from H and Me; R.sup.6 is selected from H, OMe, and OEt.