The present application relates to analogs of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.

Provided are compounds, including those of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.

Provided are compounds, including those of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.

The present invention is directed to Benzomorphan Analog compounds of the Formula I, Formula IA, Formula IB, Formula IC, or Formula ID as shown below; and related Formula I, Formula IA, Formula IB, Formula IC, or Formula ID; Formula I, Formula IA, Formula IB, Formula IC, or Formula ID; wherein R.sup.1, R.sup.2a, R.sup.2b, R.sup.3 and R.sup.4 are as defined herein. ##STR00001##
Compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors.

The present invention is directed to Benzomorphan Analog compounds of the Formula I, Formula IA, Formula IB, Formula IC, or Formula ID as shown below; and related Formula I, Formula IA, Formula IB, Formula IC, or Formula ID; Formula I, Formula IA, Formula IB, Formula IC, or Formula ID; wherein R.sup.1, R.sup.2a, R.sup.2b, R.sup.3 and R.sup.4 are as defined herein. ##STR00001##
Compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors.

In one aspect, the invention provides compounds of Formula (I) or (II): (I) or (II) and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2a, R.sup.2b, R.sup.3, R.sup.4, Z and G are defined as set forth in the disclosure. The invention also provides compounds of Formulae A and B and pharmaceutically acceptable salts and solvates thereof. Other aspects of the invention include the use of compounds of Formulae I, II, A, and B, and pharmaceutically acceptable salts and solvates thereof for the treatment of disorders responsive to modulation of one or more opioid receptors. In certain embodiments, the Compounds of the Invention are useful for treating pain. ##STR00001##

In one aspect, the invention provides compounds of Formula (I) or (II): (I) or (II) and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2a, R.sup.2b, R.sup.3, R.sup.4, Z and G are defined as set forth in the disclosure. The invention also provides compounds of Formulae A and B and pharmaceutically acceptable salts and solvates thereof. Other aspects of the invention include the use of compounds of Formulae I, II, A, and B, and pharmaceutically acceptable salts and solvates thereof for the treatment of disorders responsive to modulation of one or more opioid receptors. In certain embodiments, the Compounds of the Invention are useful for treating pain. ##STR00001##

Provided are compounds, including those of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.

Provided are compounds, including those of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.

The invention provides compounds as represented by Formula I or I and pharmaceutically acceptable salts, solvates, and diastereomers thereof: Wherein R.sup.1, R.sup.2, R.sup.2a, R.sup.3, and R.sup.4 are defined in the disclosure. The invention also provides compounds of Formulae II, III, and A-H, and pharmaceutically acceptable salts, solvates, and diastereomers thereof. In certain embodiments, Compounds of the Invention are useful for treating pain, constipation, and other conditions as delineated in the disclosure. Without wishing to be bound by any theory, it is believed that Compounds of the Invention are effective in treating conditions that are modulated by activity of opioid and/or ORL-1 receptors. ##STR00001##