Disclosed in the invention are a type of compounds having aldolase selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for inhibiting triglyceride and cholesterol synthesis, for reducing fatty acid synthesis, for preventing and/or treating obesity and type II diabetes, for preventing and/or treating tumor, for preventing and/or treating Parkinson's disease, for preventing and/or treating Alzheimer's disease or for prolonging the lifespan of mammals:

##STR00001##

Disclosed in the invention are a type of compounds having aldolase selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for inhibiting triglyceride and cholesterol synthesis, for reducing fatty acid synthesis, for preventing and/or treating obesity and type II diabetes, for preventing and/or treating tumor, for preventing and/or treating Parkinson's disease, for preventing and/or treating Alzheimer's disease or for prolonging the lifespan of mammals:

##STR00001##

The invention relates to a compound of formula (I) wherein R.sup.1—R.sup.3 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

##STR00001##

The invention relates to a compound of formula (I) wherein R.sup.1—R.sup.3 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

##STR00001##

Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.

Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.

Provided is a plant disease controlling agent that has low toxicity to humans and animals, that is excellent in handling safety, and that has an excellent controlling effect against a wide range of plant diseases and a high antimicrobial action against plant disease fungi. The present invention is a compound represented by general formula (I) below, or N-oxide or a pesticidally acceptable salt thereof: [Chem. 1]

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The present invention relates to metabolites of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine. These metabolites may act as RAGE antagonists. These metabolites may also be useful in assays to measure the presence or amount of one or more metabolites of the parent compound in a sample.

An additive, a non-aqueous electrolyte solution including the same, and a lithium secondary battery including the same are disclosed herein. In some embodiments, a non-aqueous electrolyte solution includes a lithium salt, a non-aqueous solvent including a propyl propionate, and a compound represented by Formula 1:

##STR00001##

wherein, in Formula 1, R.sub.1 and R.sub.2 are each independently hydrogen or a substituted or unsubstituted alkyl group having 1 to 6 carbon atoms.

An additive, a non-aqueous electrolyte solution including the same, and a lithium secondary battery including the same are disclosed herein. In some embodiments, a non-aqueous electrolyte solution includes a lithium salt, a non-aqueous solvent including a propyl propionate, and a compound represented by Formula 1:

##STR00001##

wherein, in Formula 1, R.sub.1 and R.sub.2 are each independently hydrogen or a substituted or unsubstituted alkyl group having 1 to 6 carbon atoms.