Patent classifications
C07D233/61
KETONE OR OXIME COMPOUND, AND HERBICIDE
There is provided novel agricultural chemicals, in particular herbicides. A ketone or oxime compound or a salt thereof of Formula (1):
##STR00001##
wherein B is a ring of any one of B-1, B-2, or B-3, Q is an oxygen atom, a sulfur atom, NOR.sup.7, etc., R.sup.6 is a hydrogen atom, C.sub.1-6 alkyl, etc., R.sup.7 is a hydrogen atom, C.sub.1-6 alkyl, etc., R.sup.8a, R.sup.8b, R.sup.9a, R.sup.9b, R.sup.10, R.sup.11, R.sup.12, R.sup.13, and R.sup.14 are each independently a hydrogen atom, C.sub.1-6 alkyl, etc., m is an integer of 1 or 2, n is an integer of 0, 1 or 2; and a herbicide including the compound or salt thereof.
Charged ion channel blockers and methods for use
The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: ##STR00001##
The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, cough, itch, and neurogenic inflammation.
Charged ion channel blockers and methods for use
The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: ##STR00001##
The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, cough, itch, and neurogenic inflammation.
IMIDAZOLE DERIVATIVES AS PRODRUGS OF DICLOFENAC
The present invention relates to a compound of formula (I):
##STR00001## wherein R.sub.1 is R.sub.3-IPU and R.sub.2 is the acyloxy residue of diclofenac, and specified by the following structures:
##STR00002## wherein OH—R.sub.3-IPU is selected from
##STR00003## and R.sub.4 and R.sub.5 may be the same or different selected from H and CH.sub.3 and salts, solvates and hydrates thereof.
FARNESOID X RECEPTOR AGONISTS AND USES THEREOF
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
IONIC COMPOUND AND COMPOSITION THEREOF FOR HYDROPHOBIC PROTEIN EXTRACTION; AND ANTI-NONSPECIFIC PROTEIN ADSORPTION ZWITTERIONIC COMPOUND AND ELEMENT WITH ANTI-NONSPECIFIC PROTEIN ADSORPTION LAYER COMPRISING THE SAME
Provided is an ionic compound, which can be formulated into an ionic solution for extracting hydrophobic proteins. The ionic solution is free of alcohol and thus advantageous for later examinations. Also provided is an anti-nonspecific protein adsorption zwitterionic compound, which can be coated on a substrate to form an anti-nonspecific protein adsorption element.
IONIC COMPOUND AND COMPOSITION THEREOF FOR HYDROPHOBIC PROTEIN EXTRACTION; AND ANTI-NONSPECIFIC PROTEIN ADSORPTION ZWITTERIONIC COMPOUND AND ELEMENT WITH ANTI-NONSPECIFIC PROTEIN ADSORPTION LAYER COMPRISING THE SAME
Provided is an ionic compound, which can be formulated into an ionic solution for extracting hydrophobic proteins. The ionic solution is free of alcohol and thus advantageous for later examinations. Also provided is an anti-nonspecific protein adsorption zwitterionic compound, which can be coated on a substrate to form an anti-nonspecific protein adsorption element.
STAT3 inhibitors and their anticancer use
In one aspect, the invention relates to substituted 6-amino-5,8-dioxo-5,8-dihydronaphthalene-1-sulfonamide analogs and derivatives thereof, substituted 4-amino-5H-naphtho[1,8-cd]isothiazol-5-one 1,1-dioxide analogs and derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
C7-Fluoro Substituted Tetracycline Compounds
The present invention is directed to a compound represented by Structural Formula (A):
##STR00001##
or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
C7-Fluoro Substituted Tetracycline Compounds
The present invention is directed to a compound represented by Structural Formula (A):
##STR00001##
or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.