Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. ##STR00001##

This invention is related to the antifungal compounds having azole structure in Formula (1), and hydrates, solvates, pharmaceutically acceptable salts or geometric isomers thereof. Formula (1). ##STR00001##

This invention is related to the antifungal compounds having azole structure in Formula (1), and hydrates, solvates, pharmaceutically acceptable salts or geometric isomers thereof. Formula (1). ##STR00001##

Carmustine may be safely and efficiently produced by reacting 2-chloroethylamine hydrochloride and 1,1′-carbonyldiimidazole to afford 1,3-bis(2-chloroethyl)-1-urea, followed by nitrosation to give the final product.

A modified polymer is obtained by grafting of at least one compound of formula (I) onto at least one unsaturation of the initial polymer chain

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in which Q represents a dipole comprising at least one nitrogen atom; A represents a divalent heteroaromatic ring optionally substituted with one or more identical or different linear or branched aliphatic hydrocarbon-based chains, optionally substituted or interrupted with one or more heteroatoms; E represents a divalent hydrocarbon-based group which may optionally contain one or more heteroatoms; R.sub.1 represents a hydrogen atom or a C.sub.1-C.sub.20 alkyl group; and Y and Z, which may be identical or different, each represent a hydrogen atom or a hydrocarbon-based chain, Y and Z together also possibly forming a ring, notably an aromatic ring, with the carbon atoms of the imidazole ring to which they are attached.

A method for extracting a rare earth metal from a mixture of one or more rare earth metals, said method comprising contacting an acidic solution of the rare earth metal with a composition which comprises an ionic liquid to form an aqueous phase and a non-aqueous phase into which the rare earth metal has been selectively extracted.

Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC3 activity.

Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC3 activity.

Disclosed are continuous processes for producing benzimidazole derivative Compound I comprising reduction of Compound 2 and reaction with valeraldehyde and conditions and apparatuses for the same.

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Disclosed are continuous processes for producing benzimidazole derivative Compound I comprising reduction of Compound 2 and reaction with valeraldehyde and conditions and apparatuses for the same.

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