Preparation and characterization of novel tamibarotene forms suitable for pharmaceutical compositions in drug delivery systems for the treatment of cancer stem cells. The tamibarotene compositions can be used for the safe and effective treatment of human diseases including a variety of cancers, cancer stem cells, drug resistant cancers, and used as a radio sensitizer.

Preparation and characterization of novel tamibarotene forms suitable for pharmaceutical compositions in drug delivery systems for the treatment of cancer stem cells. The tamibarotene compositions can be used for the safe and effective treatment of human diseases including a variety of cancers, cancer stem cells, drug resistant cancers, and used as a radio sensitizer.

The invention relates to compounds of structural formula I ##STR00001## wherein A, D, and E are independently N or C—R.sup.3, G, H, and J are independently N or C, K is N or C—H, L is N, N—R.sup.3 or C—R.sup.3, and A, D, E, G, H, J, K, and L together cannot have more than 4 N, R.sup.1 is selected from (C.sub.6 to C.sub.10) aryl, (C.sub.2 to C.sub.9) heteroaryl, and 5-indolyl, wherein each of the said (C.sub.6 to C.sub.10) aryl and (C.sub.2 to C.sub.9) heteroaryl is substituted with at least one R.sup.4a group, and wherein said (C.sub.2 to C.sub.9) heteroaryl is C-attached, and R.sup.2 is selected from the group consisting of ##STR00002##

The invention relates to compounds of structural formula I ##STR00001## wherein A, D, and E are independently N or C—R.sup.3, G, H, and J are independently N or C, K is N or C—H, L is N, N—R.sup.3 or C—R.sup.3, and A, D, E, G, H, J, K, and L together cannot have more than 4 N, R.sup.1 is selected from (C.sub.6 to C.sub.10) aryl, (C.sub.2 to C.sub.9) heteroaryl, and 5-indolyl, wherein each of the said (C.sub.6 to C.sub.10) aryl and (C.sub.2 to C.sub.9) heteroaryl is substituted with at least one R.sup.4a group, and wherein said (C.sub.2 to C.sub.9) heteroaryl is C-attached, and R.sup.2 is selected from the group consisting of ##STR00002##

The present specification relates to an organic light emitting diode.

The present specification relates to an organic light emitting diode.

An organic EL device of the disclosure includes: a first electrode and a second electrode; and an organic layer provided between the first electrode and the second electrode. The organic layer includes a light-emitting layer. The organic layer includes, between the first electrode and the light-emitting layer, a first layer that contains a polycyclic aromatic hydrocarbon compound having orientation, and a second layer that contains a larger amount of nitrogen element than the first layer.

An organic EL device of the disclosure includes: a first electrode and a second electrode; and an organic layer provided between the first electrode and the second electrode. The organic layer includes a light-emitting layer. The organic layer includes, between the first electrode and the light-emitting layer, a first layer that contains a polycyclic aromatic hydrocarbon compound having orientation, and a second layer that contains a larger amount of nitrogen element than the first layer.

Provided herein multifunctional compounds that bind and modify nucleic acids, forming crosslinks between the nucleic acid strands. In particular embodiments, the multifunctional nucleic-acid binding/modifying compounds are selective for nucleic acids of non-viable cells and viruses (i.e., they are excluded from or degraded within viable cells and viruses), and therefore find use in methods for detecting or discriminating viable and non-viable cells/viruses and nucleic acids therefrom.

Provided herein multifunctional compounds that bind and modify nucleic acids, forming crosslinks between the nucleic acid strands. In particular embodiments, the multifunctional nucleic-acid binding/modifying compounds are selective for nucleic acids of non-viable cells and viruses (i.e., they are excluded from or degraded within viable cells and viruses), and therefore find use in methods for detecting or discriminating viable and non-viable cells/viruses and nucleic acids therefrom.