Patent classifications
C07D239/26
GLP-1 receptor modulators
Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as products containing such compounds, and methods of their use and synthesis. Such compounds have the structure of Formula (I) below: (I) or pharmaceutically acceptable salts thereof, wherein A, J, W.sup.1, Y, Z, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein. ##STR00001##
NOVEL HYDRAZONE DERIVATIVE IN WHICH TERMINAL AMINE GROUP IS SUBSTITUTED WITH ARYL GROUP OR HETEROARYL GROUP, AND USE THEREOF
- Ae Nim Pae ,
- Yun Kyung Kim ,
- Sang Min LIM ,
- Sungsu LIM ,
- Jihye SEONG ,
- Jae Wook Lee ,
- Ji Yeon Song ,
- Seulgi SHIN ,
- Hyean Jeong JEONG ,
- Woo Seung SON ,
- Haeun LEE ,
- Da Mi LIM ,
- Seok Kyu KIM ,
- Jee Yun AHN ,
- Chae Won KIM ,
- Ashwini Machhindra LONDHE ,
- Lizaveta GOTINA ,
- Hyojin KIM ,
- Hye Yeon LEE ,
- Nam Gyung KIM ,
- Eunji CHA ,
- Kunhee KIM ,
- Ji Woong LIM
The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.
NOVEL HYDRAZONE DERIVATIVE IN WHICH TERMINAL AMINE GROUP IS SUBSTITUTED WITH ARYL GROUP OR HETEROARYL GROUP, AND USE THEREOF
- Ae Nim Pae ,
- Yun Kyung Kim ,
- Sang Min LIM ,
- Sungsu LIM ,
- Jihye SEONG ,
- Jae Wook Lee ,
- Ji Yeon Song ,
- Seulgi SHIN ,
- Hyean Jeong JEONG ,
- Woo Seung SON ,
- Haeun LEE ,
- Da Mi LIM ,
- Seok Kyu KIM ,
- Jee Yun AHN ,
- Chae Won KIM ,
- Ashwini Machhindra LONDHE ,
- Lizaveta GOTINA ,
- Hyojin KIM ,
- Hye Yeon LEE ,
- Nam Gyung KIM ,
- Eunji CHA ,
- Kunhee KIM ,
- Ji Woong LIM
The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.
Phenylamine compounds
The present invention relates to 4-substituted phenylamidine derivatives of the general formula (I), wherein R5-R6, ArA4, D, G, B, Q and an integer m have the meanings as defined in the description. The invention further relates to methods for their preparation and use of said compounds for controlling undesired phytopathogenic microorganisms, and agents for said purpose, comprising said phenylamine derivatives. This invention further relates to a method for controlling undesired phytopathogenic microorganisms by application of said 4-substituted phenylamidine derivatives of general formula (I) to such undesired microorganisms and/or to their habitat, according to the invention.
Phenylamine compounds
The present invention relates to 4-substituted phenylamidine derivatives of the general formula (I), wherein R5-R6, ArA4, D, G, B, Q and an integer m have the meanings as defined in the description. The invention further relates to methods for their preparation and use of said compounds for controlling undesired phytopathogenic microorganisms, and agents for said purpose, comprising said phenylamine derivatives. This invention further relates to a method for controlling undesired phytopathogenic microorganisms by application of said 4-substituted phenylamidine derivatives of general formula (I) to such undesired microorganisms and/or to their habitat, according to the invention.
Benzocarbonyl compounds
Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.
Benzocarbonyl compounds
Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.
META-DIAMIDE INSECTICIDES
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein Q, Y, R.sup.1a, R.sup.1b, Z, W, R.sup.2, R.sup.3, R.sup.4, m, R.sup.5a and R.sup.5b are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.
##STR00001##
PHOSPHINE REAGENTS FOR AZINE FLUOROALKYLATION
A new set of bench-stable fluoroalkylphosphines that directly convert C—H bonds in pyridine building blocks, drug-like fragments, and pharmaceuticals, into fluoroalkyl derivatives. No pre-installed functional groups or directing motifs are required. The reaction tolerates a variety of sterically and electronically distinct pyridines and is exclusively selective for the 4-position in most cases. The reaction proceeds via initial phosphonium salt formation followed by sp.sup.2-sp.sup.3 phosphorus ligand-coupling, an underdeveloped manifold for C—C bond formation.
Compound and organic light emitting device using the same
The present disclosure relates to a compound represented by Chemical Formula 1 and an organic light emitting device using the same. The compound is used as a material of an organic material layer of the organic light emitting device. ##STR00001##