The present disclosure provides pyrimidines of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein A.sup.1, X, A.sup.2, G, Y, n, R.sup.2a, R.sup.2b, and R.sup.3 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I and the pharmaceutically acceptable salts and solvates thereof to treat a disorder responsive to the blockade of one or more sodium channels. In one embodiment, compounds of the present disclosure are useful for treating pain. ##STR00001##

The present disclosure provides pyrimidines of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein A.sup.1, X, A.sup.2, G, Y, n, R.sup.2a, R.sup.2b, and R.sup.3 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I and the pharmaceutically acceptable salts and solvates thereof to treat a disorder responsive to the blockade of one or more sodium channels. In one embodiment, compounds of the present disclosure are useful for treating pain. ##STR00001##

Compounds of the formula (I), in which the substituents are as defined in claim 1, are suitable for use as nematicides. ##STR00001##

Compounds of the formula (I), in which the substituents are as defined in claim 1, are suitable for use as nematicides. ##STR00001##

The invention relates to substituted phenylpyrimidine hydrazides of the general formula (I) and their agrochemically acceptable salts

##STR00001##

and to their use in the crop protection sector.

In formula (I), the substituent R.sup.2 represents a hydrazine group. The substituents R.sup.1 and R.sup.3 to R.sup.7 represent radicals such as hydrogen, halogen, amino, nitro and alkyl.

The invention relates to substituted phenylpyrimidine hydrazides of the general formula (I) and their agrochemically acceptable salts

##STR00001##

and to their use in the crop protection sector.

In formula (I), the substituent R.sup.2 represents a hydrazine group. The substituents R.sup.1 and R.sup.3 to R.sup.7 represent radicals such as hydrogen, halogen, amino, nitro and alkyl.

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

##STR00001##

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

##STR00001##

Disclosed is a substituted pyrimidine compound having a structure as represented by formula PY. ##STR00001## See the description for the definition of each substituent in the formula. The compound of the present invention provides broad-spectrum bactericidal, pesticidal, and acaricidal activities, provides great control effects against plant diseases such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, and cucumber gray mold, specifically provides improved control effects against cucumber downy mildew, corn rust, wheat powdery mildew, and rice blast, provides great control effects against aphid, carmine spider mite, diamondback moth, and armyworm, and acquires great effects at a minimal dosage. The compound of the present invention also provides characteristics such as a simplified preparation method.

Disclosed is a substituted pyrimidine compound having a structure as represented by formula PY. ##STR00001## See the description for the definition of each substituent in the formula. The compound of the present invention provides broad-spectrum bactericidal, pesticidal, and acaricidal activities, provides great control effects against plant diseases such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, and cucumber gray mold, specifically provides improved control effects against cucumber downy mildew, corn rust, wheat powdery mildew, and rice blast, provides great control effects against aphid, carmine spider mite, diamondback moth, and armyworm, and acquires great effects at a minimal dosage. The compound of the present invention also provides characteristics such as a simplified preparation method.