The invention relates to compounds which are inhibitors of the polymerization of tubulin, to the methods for the production thereof, and to the uses of same.

This present invention includes novel ligands for metal complexes, which include three fused cycles or heterocycles. The first ring may be either a pyridine or a pyrimidine ring, which coordinates with the iridium metal. The second ring may be a six-membered ring, which may or may not contain nitrogen atoms. The third ring may be either a five or six membered ring. The combination of these aromatic rings provides near infrared or infrared emission in PHOLEDs devices. The bottom ring of the ligand is an alkylated cycle or heterocycle which provides a good efficiency and emission line shape.

This present invention includes novel ligands for metal complexes, which include three fused cycles or heterocycles. The first ring may be either a pyridine or a pyrimidine ring, which coordinates with the iridium metal. The second ring may be a six-membered ring, which may or may not contain nitrogen atoms. The third ring may be either a five or six membered ring. The combination of these aromatic rings provides near infrared or infrared emission in PHOLEDs devices. The bottom ring of the ligand is an alkylated cycle or heterocycle which provides a good efficiency and emission line shape.

This present invention includes novel ligands for metal complexes, which include three fused cycles or heterocycles. The first ring may be either a pyridine or a pyrimidine ring, which coordinates with the iridium metal. The second ring may be a six-membered ring, which may or may not contain nitrogen atoms. The third ring may be either a five or six membered ring. The combination of these aromatic rings provides near infrared or infrared emission in PHOLEDs devices. The bottom ring of the ligand is an alkylated cycle or heterocycle which provides a good efficiency and emission line shape.

This present invention includes novel ligands for metal complexes, which include three fused cycles or heterocycles. The first ring may be either a pyridine or a pyrimidine ring, which coordinates with the iridium metal. The second ring may be a six-membered ring, which may or may not contain nitrogen atoms. The third ring may be either a five or six membered ring. The combination of these aromatic rings provides near infrared or infrared emission in PHOLEDs devices. The bottom ring of the ligand is an alkylated cycle or heterocycle which provides a good efficiency and emission line shape.

The present application relates to compounds comprising an ester, a thioester, or a hydrazide moiety and methods of synthesizing these compounds. The present application also relates to pharmaceutical compositions containing the compounds and methods of treating cell proliferative disorders mediated by the Hedgehog (Hh) signaling pathway, such as cancer, by administering the compounds and pharmaceutical compositions to subjects in need thereof.

The present application relates to compounds comprising an ester, a thioester, or a hydrazide moiety and methods of synthesizing these compounds. The present application also relates to pharmaceutical compositions containing the compounds and methods of treating cell proliferative disorders mediated by the Hedgehog (Hh) signaling pathway, such as cancer, by administering the compounds and pharmaceutical compositions to subjects in need thereof.

The invention relates to compounds according to the general formula (1), and to the use thereof for production of a medicament, especially for treatment of a disorder associated with bromodomains, such as cancer.

The invention relates to compounds according to the general formula (1), and to the use thereof for production of a medicament, especially for treatment of a disorder associated with bromodomains, such as cancer.