The utility model relates to an illumination device (100) for tear film lipid layer on ocular surface attached to an Ophthalmic Slit lamp Microscope, which comprises a ophthalmic slit lamp microscope. An illumination device (100) for tear film lipid layer is installed on the slit lamp microscope. The illumination device (100) is located at the lower part of the observer’s eye to illuminate the surface of the lower half of the eye surface angular membrane of the observer’s eye for observing the tear film lipid layer. The light emitted by the light source of the eye surface tear film lipid layer illumination device is inclined relative to the eye axis direction (10), and its inclination angle is ≥ 20°, which reduces the noise interference of transparent parts such as iris behind the cornea, reduces the noise, and improves the observation and imaging clarity of the eye surface lipid layer.

One embodiment is directed to a system comprising a head-mounted member removably coupleable to the user's head; one or more electromagnetic radiation emitters coupled to the head-mounted member and configured to emit light with at least two different wavelengths toward at least one of the eyes of the user; one or more electromagnetic radiation detectors coupled to the head-mounted member and configured to receive light reflected after encountering at least one blood vessel of the eye; and a controller operatively coupled to the one or more electromagnetic radiation emitters and detectors and configured to cause the one or more electromagnetic radiation emitters to emit pulses of light while also causing the one or more electromagnetic radiation detectors to detect levels of light absorption related to the emitted pulses of light, and to produce an output that is proportional to an oxygen saturation level in the blood vessel.

One embodiment is directed to a system comprising a head-mounted member removably coupleable to the user's head; one or more electromagnetic radiation emitters coupled to the head-mounted member and configured to emit light with at least two different wavelengths toward at least one of the eyes of the user; one or more electromagnetic radiation detectors coupled to the head-mounted member and configured to receive light reflected after encountering at least one blood vessel of the eye; and a controller operatively coupled to the one or more electromagnetic radiation emitters and detectors and configured to cause the one or more electromagnetic radiation emitters to emit pulses of light while also causing the one or more electromagnetic radiation detectors to detect levels of light absorption related to the emitted pulses of light, and to produce an output that is proportional to an oxygen saturation level in the blood vessel.

A method for determining thickness of layers of the tear film includes reconstructing a full- or hyper-spectral interference pattern from an imaged multi-spectral pattern. Tear film thickness can then be estimated from the full- or hyper-spectral interference pattern. Using a full- or hyper-spectral interference pattern provides a greater number of frequency sampling points for increased tear film thickness estimation accuracy, without traditional time consuming techniques.

A medical diagnostic device and method, the device including: (a) an alternating current source, adapted to produce an alternating current; (b) an electrode arrangement having at least first and second electrodes, separated by an electrically insulating region, the arrangement having an at least semi-rigid region that fixes the electrodes in a spaced-apart manner, the arrangement adapted to contact the soft tissue on the inner surface of the eyelid; and (c) a processor, associated with the electrode arrangement, said electrodes electrically connected to the alternating current source; wherein, when the electrode arrangement is provided with the alternating current, and is disposed against the soft tissue, the soft tissue electrically bridges between the electrodes to form an electrical circuit, wherein an electrical signal is produced by the alternating current electrically passing between the electrodes via the soft tissue; wherein the processor is adapted to receive in-vivo based electrical information originating from the electrical signal, via the circuit, and to produce an output relating to, or derived from, the moisture parameter, based on the in-vivo electrical information; and wherein the processor is designed and configured to compute the moisture parameter in the soft tissue, at least partially based on the in-vivo electrical information, and based on an empirical correlation between the in-vivo electrical information and the moisture parameter.

Ocular surface interferometry devices, systems, and methods are disclosed for imaging an ocular tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image, wherein the specularly reflected light may be produced from various portions of the ocular tear film by obliquely illuminating various portions of the ocular tear film with a multi-wavelength light source, such as in a tiling pattern(s). The imaging device can also be focused on the lipid layer to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image, which can used to measure a tear film layer thickness.

A composition for detecting biofilm on an eyelid margin includes a dye that binds to the biofilm and a solution that is biocompatible with the eye. A method for detecting biofilm on an eyelid margin of an eye includes applying a solution to the eye or the eyelid margin so that a dye in the solution binds to the biofilm. A handheld camera for detecting biofilm on an eyelid margin of an eye includes a housing, an image sensor, and a lens including a focal length determined by a distance between the lens and the eyelid margin. A method for detecting biofilm on an eyelid margin includes capturing an image of the eyelid margin using a handheld camera and determining if the biofilm is present on the eyelid margin. A system for detecting biofilm on an eyelid margin of an eye includes a composition and a handheld camera.

The present invention provides a device for an energizable Ophthalmic Lens with an event coloration mechanism. The event coloration mechanism may color or change color based on some predefined event. For example, a predefined constituent or predefined condition of the tear fluid may be indicative of the predefined event, and the event coloration mechanisms may interact with the tear fluid, accordingly. The event coloration mechanism may provide the energizable functionality of the Ophthalmic Lens in some embodiments. In others, the event coloration mechanism may be passive but may interact and interface with the electrical components of the Ophthalmic Lens, such as, for example, those included within the Media Insert. Event coloration mechanisms may be combined with additional functionalities that may be included in an energizable Ophthalmic Lens.

Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for peak detection and/or determining stabilization of an ocular tear film. Embodiments disclosed herein also include various image capturing and processing methods and related systems for providing various information about a patient's ocular tear film (e.g., the lipid and aqueous layers) and a patient's meibomian glands that can be used to analyze tear film layer thickness(es) (TFLT), and related characteristics as it relates to dry eye.

Systems and methods for device and content management include determining a user is viewing virtual reality content from a user device, and receiving, through a network from the user device, body information associated with the user while the user is viewing the virtual reality content. A user device management configuration associated with the body information is determined. A user device management action is retrieved using the user device management configuration. A notification associated with the user device management action that causes the user device to perform the user device management action and modify the virtual reality content being viewed by the user is sent through the network to the user device.