Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user's body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user's body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

A contact lens according to an embodiment of the present disclosure includes a lens section attachable to an eyeball, and one or a plurality of structure portions provided in the lens section and intended to accumulate tears. This makes it possible to, for example, measure an absorption spectrum of the tears, by emitting light toward the tears accumulated in the one or plurality of structure portions.

According to some aspects, a device is presented herein that is configured to be located underneath an eyelid and worn by a user for treating dry eye. The device includes a first surface configured to face a portion of a sclera of the eye, and a second surface configured to face an eyelid and to be completely covered by the eyelid. In some embodiments, the device further includes a plurality of stimulation electrodes proximal to the first surface, wherein the plurality of stimulation electrodes is configured to stimulate the sclera. The device further includes an energy storage element coupled to the plurality of stimulation electrodes. The energy storage element is configured to supply power to the plurality of stimulation electrodes. The device further includes a processor configured to control a supply of energy from the energy storage element to the plurality of stimulation electrodes to stimulate the sclera.

Optical sensors, systems and methods of use thereof are provided. Aspects of the subject systems include a sensor having a sensing surface and a configuration that directs a first optical signal to interact with the sensing surface at a first incident angle, and directs a second optical signal to interact with the sensing surface at a second incident angle. The subject sensors, systems and methods find use, e.g., in the diagnosis of dry eye disease.

Systems and methods for assessing multi-layer structures in which a spectrum array is generated from low coherence interferometry and input into a statistical estimator, which determines the thickness and layer number based on the inputted spectrum and other information, including information about a source intensity noise, Poisson noise, and dark noise associated with the low coherence interferometry.

A system for treating dry eye is presented. According to some aspects, the system includes an underlid device having an anterior surface and a posterior surface, wherein the anterior surface is configured to contact a portion of an eyelid, and wherein the posterior surface is configured to contact a portion of an eyeball. The underlid device further includes a Peltier heat pump. The Peltier heat pump includes a first surface configured to heat the eyelid when the device is positioned between the eyelid and the eyeball, and a second surface configured to cool a portion of a surface of the eyeball when the device is positioned between the eyelid and the eyeball. The underlid device further includes an energy storage element coupled to the Peltier heat pump and configured to supply power to the Peltier heat pump.

An ophthalmologic apparatus includes: an objective lens 18 configured to face a subject's eye E; an illumination optical system 1c configured to irradiate the subject's eye E with illumination light L1; a measurement optical system 1 b configured to take an interference image of corneal reflection light R1, which is a reflection of the illumination light L1, through the objective lens 18; an observation optical system 1a configured to image an anterior segment of the subject's eye E through the objective lens 18; a control unit 2 configured to process information on imaging by the measurement optical system 1b and the observation optical system 1 a; and the control unit 2 configured to simultaneously output, to a single output unit 3, tear film information calculated from the interference image by the measurement optical system 1 b, and information on the anterior segment E imaged by the observation optical system 1a.

Methods, systems, and devices to improve the assessment of visual function and overcoming limitations of current methods to identify the visual function that potentially could be reached by a given eye. Multiple eye tests including visual stimuli plus optical measurement components, and methods to combine the results, identify and quantify sources of decreased vision resulting from optical sources, such as a lens and cornea as distinguished from retinal sources. By identifying potentially correctable optical sources of decreased vision, and overcoming physiological limitations such as size of the eye's pupil, the visual benefits of treatment such as by cataract or corneal surgery are distinguished from retinal pathology that requires medical intervention. The devices and methods provide metrics that include an expected value of the visual function and sources of variability including both optical and neural components, to guide treatment and improve clinical trials.

The present invention relates to a glucose detecting complex and a contact lens-type sensor comprising the same for detecting glucose in tears. The contact lens-type sensor for detecting glucose according to the present invention includes a complex in which glucose oxidase is coupled to cerium oxide nanoparticles. Such a configuration allows the visualization of changes in glucose concentrations and the quantitative measured of glucose in a simpler and more economical way. In addition, glucose concentrations can be monitored in real time through a non-invasive method by measuring the concentration of glucose in tears rather than in blood in comparison with the conventional blood glucose measurement method. Therefore, the present invention can be widely applied in the technical field for the early diagnosis and prevention of diabetes.