C07D263/16

Azoline compounds
09968087 · 2018-05-15 · ·

The present invention relates to azoline compounds of formula I ##STR00001##
wherein A, B.sup.1, B.sup.2, B.sup.3, G.sup.1, G.sup.2, X.sup.1, R.sup.1, R.sup.3a, R.sup.3b, R.sup.g1 and R.sup.g2 are as defined in the claims and the description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

Oleic acid derivatives, pharmaceutical composition or food composition comprising said oleic acid derivatives, and their uses

Disclosed is an oleic acid derivative including a hydrophobic part C17H33 linked to a particular polar head part A, especially for use as a medicament, for instance, for the treatment of a disorder caused by the GPR120 receptor and/or the CD36 receptor, including administering to a subject in need thereof a therapeutically effective amount of the oleic acid derivative or of the pharmaceutical composition. Also disclosed is the use of the oleic acid derivative as a food composition.

Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors

The present invention provides compounds of formula (I) or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein W, X, n, s, t, and Ra are as described herein. The present invention relates generally to selective inhibitors of histone deacetylase and to methods of making and using them. ##STR00001##

Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors

The present invention provides compounds of formula (I) or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein W, X, n, s, t, and Ra are as described herein. The present invention relates generally to selective inhibitors of histone deacetylase and to methods of making and using them. ##STR00001##

BENZOYLGLYCINE DERIVATIVES AND METHODS OF MAKING AND USING SAME

Disclosed are compounds of formulae:

##STR00001##

and pharmaceutically acceptable salts thereof, wherein the variables, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.11, R.sub.12, R.sub.13, R.sub.14, R.sub.15, R.sub.16, R.sub.17, n, and m are defined herein. These compounds are usefl for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.

BENZOYLGLYCINE DERIVATIVES AND METHODS OF MAKING AND USING SAME

Disclosed are compounds of formulae:

##STR00001##

and pharmaceutically acceptable salts thereof, wherein the variables, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.11, R.sub.12, R.sub.13, R.sub.14, R.sub.15, R.sub.16, R.sub.17, n, and m are defined herein. These compounds are usefl for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.

Processes for removing carbon disulfide from symmetrical and asymmetrical sulfide product streams

Processes for removing carbon disulfide from product streams containing a sulfide compound are performed by contacting the product stream with an alkanolamine and converting the carbon disulfide to a higher boiling point product, thereby reducing or eliminating carbon disulfide from the product stream. Subsequent removal of the higher boiling point product via distillation can lead to a purified sulfide stream with high purity.

Ethynylbenzene Derivatives
20170349544 · 2017-12-07 ·

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R.sub.1, R.sub.2, R.sub.3, R.sub.101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.

##STR00001##

Ethynylbenzene Derivatives
20170349544 · 2017-12-07 ·

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R.sub.1, R.sub.2, R.sub.3, R.sub.101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.

##STR00001##

Hematopoietic growth factor mimetic small molecule compounds and their uses

The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.