Patent classifications
C07D265/38
Amide compound, and Pin1 inhibitor, therapeutic agent for inflammatory diseases and therapeutic agent for cancer that use the same
The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. The invention provides: a compound represented by formula (I) or a salt thereof; and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic or prophylactic agent for inflammatory diseases, a therapeutic or prophylactic agent for cancer, and a therapeutic or prophylactic agent for adiposity that use said compound/salt. ##STR00001##
Amide compound, and Pin1 inhibitor, therapeutic agent for inflammatory diseases and therapeutic agent for cancer that use the same
The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. The invention provides: a compound represented by formula (I) or a salt thereof; and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic or prophylactic agent for inflammatory diseases, a therapeutic or prophylactic agent for cancer, and a therapeutic or prophylactic agent for adiposity that use said compound/salt. ##STR00001##
Near-infrared nerve-sparing fluorophores
The compounds provided herein are phenoxazines that can be used as far red to near-infrared nerve-sparing fluorescent compounds in medical procedures.
OXAZINE-BASED WATER-SOLUBLE FLUOROPHORE COMPOUNDS FOR IN VIVO NERVE IMAGING
This invention provides novel oxazine-based, water soluble fluorophore compounds useful in in vivo nerve imaging, as well as compositions comprising them and methods for their use.
OXAZINE-BASED WATER-SOLUBLE FLUOROPHORE COMPOUNDS FOR IN VIVO NERVE IMAGING
This invention provides novel oxazine-based, water soluble fluorophore compounds useful in in vivo nerve imaging, as well as compositions comprising them and methods for their use.
NERVE SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION
Nerve-specific fluorophore formulations of Formula (I) for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions.
##STR00001##
Green light thermally activated delayed fluorescent material and synthesizing method thereof, and electroluminescent device
A green light thermally activated delayed fluorescent material and a synthesizing method thereof, and an electroluminescent device are described. The green light thermally activated delayed fluorescent material is a target compound reacted and synthesized by an electron donor and an electron acceptor. The target compound is a D-A molecular structure. The electron acceptor has a fluorine-containing group and a bromine-containing group. The electron acceptor is a planar electron acceptor with an ultra-low triplet state energy level, and a triplet state energy level of the target compound ranges from 1.0 to 2.0 eV. The synthesized green light thermally activated delayed fluorescent material improves a luminous efficiency and realizes a preparation of a high efficiency organic electroluminescent device.
Green light thermally activated delayed fluorescent material and synthesizing method thereof, and electroluminescent device
A green light thermally activated delayed fluorescent material and a synthesizing method thereof, and an electroluminescent device are described. The green light thermally activated delayed fluorescent material is a target compound reacted and synthesized by an electron donor and an electron acceptor. The target compound is a D-A molecular structure. The electron acceptor has a fluorine-containing group and a bromine-containing group. The electron acceptor is a planar electron acceptor with an ultra-low triplet state energy level, and a triplet state energy level of the target compound ranges from 1.0 to 2.0 eV. The synthesized green light thermally activated delayed fluorescent material improves a luminous efficiency and realizes a preparation of a high efficiency organic electroluminescent device.
Bisanthracene Derivatives Having Solubilizing Substituent, and Organic Electroluminescence Device Using Same
The present invention is to provide a light emitting material, for an organic EL device, exhibiting higher light emitting efficiency, and particularly, to provide a blue light emitting material, wherein the light emitting material comprises a compound of the following General Formula (1):
##STR00001## X is an aryl group including a tertiary amine structure, and Y is a phenyl group having an alkyl or aryl substituent at one ortho position.
Bisanthracene Derivatives Having Solubilizing Substituent, and Organic Electroluminescence Device Using Same
The present invention is to provide a light emitting material, for an organic EL device, exhibiting higher light emitting efficiency, and particularly, to provide a blue light emitting material, wherein the light emitting material comprises a compound of the following General Formula (1):
##STR00001## X is an aryl group including a tertiary amine structure, and Y is a phenyl group having an alkyl or aryl substituent at one ortho position.