Patent classifications
C07D277/06
SUBSTITUTED PYRROLIDINES AS G-PROTEIN COUPLED RECEPTOR 43 AGONISTS
The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
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SUBSTITUTED PYRROLIDINES AS G-PROTEIN COUPLED RECEPTOR 43 AGONISTS
The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
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COVALENT BTK INHIBITORS AND USES THEREOF
The present invention features compounds having BTK inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cardiovascular diseases, respiratory diseases, inflammation, and diabetes.
Substituted pyrrolidines as G-protein coupled receptor 43 agonists
The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases. ##STR00001##
Substituted pyrrolidines as G-protein coupled receptor 43 agonists
The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases. ##STR00001##
NOVEL IMAGING COMPOSITION AND USES THEREOF
The invention discussed in this application relates to hydroxamic acid-based compounds that are useful as imaging agents when bound to an appropriate metal centre, particularly for the imaging of tumours.
NOVEL IMAGING COMPOSITION AND USES THEREOF
The invention discussed in this application relates to hydroxamic acid-based compounds that are useful as imaging agents when bound to an appropriate metal centre, particularly for the imaging of tumours.
INHIBITION OF GLUTAMINASE C
The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.
INHIBITION OF GLUTAMINASE C
The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.
Imaging composition and uses thereof
The invention discussed in this application relates to hydroxamic acid-based compounds that are useful as imaging agents when bound to an appropriate metal centre, particularly for the imaging of tumours.