The present invention relates to a benzene ring compound and a use thereof. In particular, provided is a compound as shown in formula I, or an optical isomer thereof or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof. The present compound has good therapeutic effects on tumors

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The present invention relates to a benzene ring compound and a use thereof. In particular, provided is a compound as shown in formula I, or an optical isomer thereof or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof. The present compound has good therapeutic effects on tumors

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The present disclosure relates to a novel class of bifunctional molecules that are useful in a targeted or selective degradation of a protein.

A novel carboxylate luciferin substrate or methotrexate compound is disclosed as having at least one substituted benzyl ester group masking a carboxyl group. The substituted benzyl ester group may have a stabilizing substitution on the benzylic position. The stabilizing substitution on the benzylic position may be a methyl, phenyl group or a branched C.sub.3-C.sub.5 alkyl group. The luciferin substrate may provide an imaging agent or ABS may have NIR BL activity. Optionally, there is a trigger group at the para position or ortho position, or optionally both.

A novel carboxylate luciferin substrate or methotrexate compound is disclosed as having at least one substituted benzyl ester group masking a carboxyl group. The substituted benzyl ester group may have a stabilizing substitution on the benzylic position. The stabilizing substitution on the benzylic position may be a methyl, phenyl group or a branched C.sub.3-C.sub.5 alkyl group. The luciferin substrate may provide an imaging agent or ABS may have NIR BL activity. Optionally, there is a trigger group at the para position or ortho position, or optionally both.

The present disclosure relates to the field of pharmaceutical chemistry and biotechnology. The present disclosure also relates to a compound of Formula I and a process of preparation thereof. The disclosure furthermore relates to methods/use of Formula I compounds as DNA probes. Said Formula I compounds are employed for recognizing specific DNA sequences by near Infra-red (NIR)-Fluorescence Switch-on mechanism, and have related applications including but not limited to cell imaging. Also, method of treating parasitic infections by employing the present compound of Formula I is provided.

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Compounds represented by structural formulas described herein, such as Structural Formula (I):

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or a pharmaceutically acceptable salt thereof are useful in treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.

Compounds represented by structural formulas described herein, such as Structural Formula (I):

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or a pharmaceutically acceptable salt thereof are useful in treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.

A compound that is suitably used for formation of an optically anisotropic film having excellent reverse wavelength dispersibility and moisture-heat resistance; a polymerizable composition; an optically anisotropic film; an optical film; a polarizing plate; and an image display device. The present invention relates to a compound represented by Formula (I-1) P.sup.1-SP.sup.1-Ar.sup.1-Mes-Ar.sup.2-SP.sup.2-P.sup.2 (I-1).

A compound that is suitably used for formation of an optically anisotropic film having excellent reverse wavelength dispersibility and moisture-heat resistance; a polymerizable composition; an optically anisotropic film; an optical film; a polarizing plate; and an image display device. The present invention relates to a compound represented by Formula (I-1) P.sup.1-SP.sup.1-Ar.sup.1-Mes-Ar.sup.2-SP.sup.2-P.sup.2 (I-1).