The present disclosure relates to compounds of Formula (I) and their methods of use thereof. The compounds of Formula (I) are conjugated oligoelectrolytes and are suitable for use as a membrane probe to label and/or detect cells and/or lipid vesicles and thus in flow cytometry applications. The present disclosure also relates to a flow system for detecting and/or quantifying cells and/or lipid vesicles.

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The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the haematopoietic system including the haematologic system in human and veterinary medicine.

Disclosed are compounds of Formula (I) or a salt or prodrug thereof, wherein: X is CR.sub.4a or N; Y is CR.sub.4b or N; Z is CR.sub.4d or N; provided that zero or 1 of X, Y, and Z is N; and R.sub.1, R.sub.2, R.sub.3, R.sub.4a, R.sub.4b, R.sub.4c, and R.sub.4d are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer. ##STR00001##

Disclosed are compounds of Formula (I) or a salt or prodrug thereof, wherein: X is CR.sub.4a or N; Y is CR.sub.4b or N; Z is CR.sub.4d or N; provided that zero or 1 of X, Y, and Z is N; and R.sub.1, R.sub.2, R.sub.3, R.sub.4a, R.sub.4b, R.sub.4c, and R.sub.4d are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer. ##STR00001##

The present disclosure provides inhibitors of microorganisms including viruses and fungi of the formula (I) or (II) wherein the variables are defined herein. Also provided are methods of treatment using these agents in the treatment of infections of microorganisms such as viruses and fungi. ##STR00001##

The present disclosure provides inhibitors of microorganisms including viruses and fungi of the formula (I) or (II) wherein the variables are defined herein. Also provided are methods of treatment using these agents in the treatment of infections of microorganisms such as viruses and fungi. ##STR00001##

Methods and compositions for controlling, treating, preventing, or ameliorating arthropod infection are provided. Compositions can comprise one or more active agents of small molecules antagonists of arthropod kinin receptor. Methods of preventing disease development and infestation by arthropods are disclosed as well as methods of making, using, and producing such compositions.

Methods and compositions for controlling, treating, preventing, or ameliorating arthropod infection are provided. Compositions can comprise one or more active agents of small molecules antagonists of arthropod kinin receptor. Methods of preventing disease development and infestation by arthropods are disclosed as well as methods of making, using, and producing such compositions.

The invention provides isothiazolylcarboxamide compounds, pharmaceutical compositions, their use for inhibiting mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT 1), and their use in the treatment of a disease or condition, such as a proliferative disorder, inflammatory disorder, or autoimmune disorder.

The invention provides isothiazolylcarboxamide compounds, pharmaceutical compositions, their use for inhibiting mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT 1), and their use in the treatment of a disease or condition, such as a proliferative disorder, inflammatory disorder, or autoimmune disorder.