The invention provides methods and kits for detecting, screening, quantifying or localizing the etiology for reduced or impaired cranial nerve function or conduction; localizing a central nervous system lesion; detecting, diagnosing or screening for increased intracranial pressure, pressure or disruption of central nervous system physiology as seen with concussion; or detecting, diagnosing, monitoring progression of or screening for a disease or condition featuring increased intracranial pressure or concussion by tracking eye movement of the subject. The invention also provides methods and kits useful for detecting, screening for or quantitating disconjugate gaze or strabismus, useful for diagnosing a disease characterized by disconjugate gaze or strabismus in a subject, useful for detecting, monitoring progression of or screening for a disease or condition characterized by disconjugate gaze or strabismus in a subject or useful for quantitating the extent of disconjugate gaze or strabismus. Further, the invention provides methods for assessing or quantifying structural and non-structural traumatic brain injury or diagnosing a disease characterized by or featuring structural and non-structural traumatic brain injury.

A refraction device includes a main body, a spherical power lens coupled to the main body, an astigmatic power lens movably coupled to the main body, and a visual display coupled to the main body and oriented toward an optical pathway extending through the spherical power lens and the astigmatic power lens. The visual display is configured to display an image for testing visual acuity.

A refraction device includes a main body, a spherical power lens coupled to the main body, an astigmatic power lens movably coupled to the main body, and a visual display coupled to the main body and oriented toward an optical pathway extending through the spherical power lens and the astigmatic power lens. The visual display is configured to display an image for testing visual acuity.

A method for optimizing an ophthalmic treatment, comprising: measuring a patient's eye with an ophthalmic measurement instrument, fabricating a trial correction lens and testing it on the patient's eye, determining a score or success criteria for the trial correction, using the score or success criteria to provide training information to a machine-learning algorithm, and using the machine-learning algorithm to determine an optimal ophthalmic correction.

Method for determining a refraction of at least an eye of a person under specific spectral conditions, the method including: an eye illumination step, during which the eye of the person is illuminated under the specific spectral conditions, the specific spectral conditions being provided by a polychromatic source having a spectrum which is different from the spectrum of a white light source and/or by a chromatic filter positioned before the eye of the person and illuminated by a source; and a refraction determination step during which the refraction of the eye of the person is determined under the specific spectral conditions.

Method for determining a refraction of at least an eye of a person under specific spectral conditions, the method including: an eye illumination step, during which the eye of the person is illuminated under the specific spectral conditions, the specific spectral conditions being provided by a polychromatic source having a spectrum which is different from the spectrum of a white light source and/or by a chromatic filter positioned before the eye of the person and illuminated by a source; and a refraction determination step during which the refraction of the eye of the person is determined under the specific spectral conditions.

A method for detecting a variation of a current refractive error of a person including obtaining an optical equipment comprising an optical lens, a dioptric function of the optical lens being adapted for correcting an initial refractive error of a person, the optical equipment further comprising a processing circuit comprising a processor operably connected to a memory. The method further includes using the memory, obtaining a current value of a parameter, the current value being indicative of a variation of a current refractive error of the person with respect to the initial refractive error. The method additionally includes using the processing circuit, detecting a variation of a current refractive error of the person with respect to the initial refractive error based on the obtained current value of the parameter.

A method for detecting a variation of a current refractive error of a person including obtaining an optical equipment comprising an optical lens, a dioptric function of the optical lens being adapted for correcting an initial refractive error of a person, the optical equipment further comprising a processing circuit comprising a processor operably connected to a memory. The method further includes using the memory, obtaining a current value of a parameter, the current value being indicative of a variation of a current refractive error of the person with respect to the initial refractive error. The method additionally includes using the processing circuit, detecting a variation of a current refractive error of the person with respect to the initial refractive error based on the obtained current value of the parameter.

Generating an aspheric contact lens design for facilitating myopia control of a cornea of a patient includes operations of: obtain measurement for degree refractive error of the eye in diopters; obtain measurement of one or more biomechanical properties of the cornea; define a diameter of a central zone of the contact lens based on pupil size; select a base curve profile and width for the central zone based on the refractive error and the one or more biomechanical properties; define a width of a reverse zone adjacent to and encircling the central zone, the width being greater than 0.5 mm; select a reverse curve profile for the reverse zone compatible with the base curve profile; modify the base curve profile adjacent to the reverse zone by applying a selected base eccentricity curve profile for enhancing the tension force strength of the reverse zone; define a width of a relief zone of the contact lens adjacent to and encircling the reverse zone; select a relief curve profile for the relief zone; define a width of an alignment zone of the contact lens adjacent to and encircling the relief zone; select an alignment curve profile for the alignment zone; and define a width of a peripheral zone of the contact lens adjacent to and encircling the alignment zone; select a peripheral curve profile for the peripheral zone; wherein the compression force strength and the tension force strength of the contact lens cooperate to reshape corneal curvature in a mid-peripheral region to address the myopia control when the contact lens is applied to the eye.

Generating an aspheric contact lens design for facilitating myopia control of a cornea of a patient includes operations of: obtain measurement for degree refractive error of the eye in diopters; obtain measurement of one or more biomechanical properties of the cornea; define a diameter of a central zone of the contact lens based on pupil size; select a base curve profile and width for the central zone based on the refractive error and the one or more biomechanical properties; define a width of a reverse zone adjacent to and encircling the central zone, the width being greater than 0.5 mm; select a reverse curve profile for the reverse zone compatible with the base curve profile; modify the base curve profile adjacent to the reverse zone by applying a selected base eccentricity curve profile for enhancing the tension force strength of the reverse zone; define a width of a relief zone of the contact lens adjacent to and encircling the reverse zone; select a relief curve profile for the relief zone; define a width of an alignment zone of the contact lens adjacent to and encircling the relief zone; select an alignment curve profile for the alignment zone; and define a width of a peripheral zone of the contact lens adjacent to and encircling the alignment zone; select a peripheral curve profile for the peripheral zone; wherein the compression force strength and the tension force strength of the contact lens cooperate to reshape corneal curvature in a mid-peripheral region to address the myopia control when the contact lens is applied to the eye.