An ionizable lipid having a structure represented by the following formula (I):

##STR00001## wherein Y is independently selected from a group consisting of NH, O, S, and a single bond; X is independently selected from NR.sup.1R.sup.2 or a nitrogen-containing heteroaryl group; L.sup.1 and L.sup.2 are each independently selected from a group consisting of a C.sub.1-C.sub.10 alkylene group, a C.sub.2-C.sub.10 alkenylene group,

##STR00002##

R.sup.1 and R.sup.2 are each independently selected from a group consisting of H, a substituted or unsubstituted C.sub.1-C.sub.10 hydrocarbyl group, a substituted or unsubstituted C.sub.1-C.sub.10 heterohydrocarbyl group, a substituted or unsubstituted C.sub.6-C.sub.20 aryl group, and a substituted or unsubstituted C.sub.1-C.sub.20 heteroaryl group; R.sup.3 is a C.sub.5-C.sub.30 alkyl group; R.sup.4 is a C.sub.5-C.sub.30 alkyl group; n is an integer selected from 1 to 10; and m and p are each independently an integer selected from 1 to 20.

The present disclosure relates to a novel ionizable lipid containing a biodegradable ester bond. The ionizable lipid containing an ester bond, according to the present disclosure, stably delivers an anionic drug when prepared into lipid nanoparticles, and exhibits an excellent effect, in particular, in delivering nucleic acids, and thus can be effectively used in related technical fields such as lipid nanoparticle-mediated gene therapy.

The present disclosure relates to a novel ionizable lipid containing a biodegradable ester bond. The ionizable lipid containing an ester bond, according to the present disclosure, stably delivers an anionic drug when prepared into lipid nanoparticles, and exhibits an excellent effect, in particular, in delivering nucleic acids, and thus can be effectively used in related technical fields such as lipid nanoparticle-mediated gene therapy.