An apparatus and method for determining at least one visual refraction feature of a subject by showing a visual stimulus to the subject. The apparatus includes an optical system arranged on an optical path between an eye of the subject and the visual stimulus, the optical system being adapted to provide an optical power that is continuously variable as a function of time (t), a control unit for driving the optical power of the optical system and an input device adapted for recording a response of the subject relative to a sharpness of the visual stimulus seen through the optical system, the control unit being adapted to adjust a speed of variation of the optical power (S) as a function of the response recorded.

Pupillometry systems for measuring one or more pupillary characteristics of a patient are shown and described. The puillometry systems include at least one camera for capturing image data of one or more pupils, at least one radiation source configured to project radiation to the one or more pupils, and a computer system in data communication with the at least one camera, the computer system having a processor and a non-transitory computer-readable storage medium. The non-transitory computer-readable storage medium includes computer-readable instructions for collecting and time stamping the image data, processing the raw image data in such a way as to bring the images into conformance with standardized image parameters, identifying and measuring the one or more pupils in the image data, processing the image data to produce measurement data of change in the one or more pupillary characteristics, calculating a standardized output of measurement data for the one or more pupillary characteristics, and providing a mechanism to share or store this information with other users via a computer network. Furthermore the pupillometry system has the capability to predict expected values of pupillary indices for a given patient and display to the user the relationship between the expected value and the measured value.

A method for collecting biometric measurement data of an eye on the basis of different measurement modalities, allowing for physiologically correct, representative, and robust biometric measurement data. In the method, the measurement data for individual measurement variables and the dynamic behavior of the eye are recorded continuously at the highest possible repetition rate over the measurement time. The individual phases of the dynamics of the eye which define the limits of the phase for stable vision are analyzed on the basis of the measurement values, and only the measurement data for the individual measurement variables are output which have been detected during the phase for stable vision. Although the proposed method is provided for collecting biometric measurement data in preparation for a cataract operation, the method can also be applied to other areas of ophthalmology to generate error-free measurement data or recordings of the eye.

A computer system for determining onset of an acute coronary syndrome (ACS) event in a remote computing environment comprising one or more processors, one or more computer-readable memories, and one or more computer-readable storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors via at least one of the one or more memories is provided. The stored program instructions include capturing, using a camera, a first image at a first time of an iris and a pupil of a first eye of a user; following the capturing of the first image, identifying in the first image a first iris information; capturing, using the camera, a second image at a second time of the iris and the pupil of the first eye of the user; following the capturing of the second image, identifying in the second image a second iris information; determining whether the first iris information is within an allowable range of the second iris information; and providing an indication of a likely ACS event based on a determination of whether the first iris information is within the allowable range of the second iris information.

The present invention relates to a method to predict the risk of obtaining a stress related mood disorder or syndrome by a person, comprising a. Measuring at least three parameters comprising at least one sympathetic, one parasympathetic and one hormonal parameter during a stress response, said result of the measurement depicted as RS, RP and RH respectively; b. Estimate the value of one of these parameters by calculating it from the other two parameters; c. Predict the risk on basis of the deviation between calculated and measured value of the parameter that has been estimated in step b).

The present invention relates to sedation assessment. In order to facilitate sedation depth monitoring in an autonomous imaging setting, it is proposed to use the imaging modality itself to measure the response to suitable reflexes in order to determine the depth of sedation wherein suitable reflexes include, but are not limited to, the pupil reflex, so-called superficial reflexes and the withdrawal reflexes. In one embodiment, the pupil reflex may be measured in an MRI system by repeated interleaving of dedicated iris MR imaging with the conventional scan protocol. In another embodiment, superficial reflexes in response to stroking of the skin may be measured. This may involve a dedicated actuator that may be closely integrated with the imaging modality, e.g. an MR receive coil applied to the patient. Alternatively, remote haptic systems may be used. The reflex is then acquired with a suitable diagnostic imaging method. In another embodiment, the withdrawal reflex in response to pain may be measured. This may involve an actuator that induces sudden stitching pain or very local temperature-induced pain and that is closely integrated with the imaging modality, e.g. a pinching device integrated with a patient support or an MR receive coil applied to the patient. The reflex is then acquired with a suitable diagnostic imaging method.

A method of measuring working distance between a handheld digital device and eyes of a user, including capturing an image of at least eyes of a user via an onboard camera of the handheld digital device while the user is viewing a display of the handheld digital device and comparing an apparent angular size of a structure of the eyes or face of the user to a previously captured image of the structure of the eyes or the face that was taken in the presence of an object of known size. The method further includes calculating a working distance based on the apparent angular size of the structure of the eyes or the face; and saving at least the working distance to memory or reporting out the calculated working distance on the display. A handheld digital device programmed with an algorithm to perform the method is also included.

Electrode array for monitoring of physiological parameters and devices including or utilizing same, the electrode array including an active electrode configured to provide an electrical signal and at least two inactive electrodes configured to collect the electrical signal transferred from the active electrode, wherein each of the at least two inactive electrodes are positioned at a different predetermined distance from the active electrode.

An eye-gaze detecting device includes an image data acquisition unit configured to acquire image data of an eyeball of a test subject irradiated with detection light; a position detection unit configured to detect, from the image data, position data of pupil center of the eyeball and position data of corneal reflection center; a pupil diameter calculation unit configured to calculate a pupil diameter of the test subject from the image data; a curvature center calculation unit configured to calculate a corneal curvature radius corresponding to the pupil diameter, and obtain position data of corneal curvature center based on the position data of the corneal reflection center and the corneal curvature radius; and a point-of-gaze detection unit configured to calculate, based on the position data of the pupil center and corneal curvature center, position data of point of gaze of the test subject on a plane including a display unit.

A device and a method for determining a change in the visual comfort of a user, the device including at least one light source for stimulating at least one eye of the user, a sensing circuit facing at least one eye area of the user when the device is worn by the user, the sensing circuit being configured to remotely acquire at least one signal representative of at least one characteristic of said at least one eye area, and a controller configured to determine a change in the visual comfort of the user depending on a variation of said at least one signal acquired by the sensing circuitry.