This invention is directed to anticancer compounds, pharmaceutical compositions comprising the same, methods of making anticancer compounds, and methods of treating cancer with compounds and pharmaceutical compositions.

The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.

Disclosed herein is a class of molecules termed remodilins that inhibit serum response factor (SRF). By inhibiting SRF, a number of downstream pathways can be targeted. The remodilins can be used to treat glaucoma, inhibit tumor cell growth, inhibit tumor metastasis, inhibit hypoxia-induced response, and/or reduce cellular metabolism.

A melt additive compound has the general formula (I) wherein R represents a linear alkylene group having from 1 to 18 carbon atoms; n represents an integer from 1 to 4, inclusive; and R.sub.f.sup.1 is represented by the general formula II wherein R.sub.f represents a perfluorinated group having from 3 to 5 carbon atoms. Compositions comprising a thermoplastic polymer and the melt additive compound, methods of extruding them and extruded articles are also disclosed. ##STR00001##

This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.

This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.

A melt additive compound has the general formula (I) wherein R represents a linear alkylene group having from 1 to 18 carbon atoms; n represents an integer from 1 to 4, inclusive; and R.sub.f.sup.1 is represented by the general formula II wherein R.sub.f represents a perfluorinated group having from 3 to 5 carbon atoms. Compositions comprising a thermoplastic polymer and the melt additive compound, methods of extruding them and extruded articles are also disclosed.

##STR00001##

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).

##STR00001##

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).

##STR00001##

The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.