Patent classifications
C
C07
C07D
301/00
C07D301/02
C07D301/24
C07D301/26
C07D301/26
Process for preparation of intermediates
12559466
·
2026-02-24
·
·
Disclosed herein is a process for preparation of 1-chloro-2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)propan-2-ol (compound of formula (I)) and 2-(1-chlorocyclopropyl)-2-[(2-chlorophenyl)methyl]oxirane (compound of formula (II)), which are synthetic intermediates in the preparation of triazole fungicides. The process comprises reacting a Grignard reagent of 2-chlorobenzyl halide with 1-chloro-1-chloroacetylcyclopropane, wherein said reaction is carried out at temperatures between 0 C. and 100 C. and characterized in that said reaction is carried out in a solvent system comprising methyl tetrahydrofuran and toluene.