A compound of the following formula

##STR00001##

capable of binding to a tripartite motif (TRIM) protein E3 ubiquitin ligase (TRIM21). This application also provides a method for treating a disease associated with abnormal cell proliferation with the compound of formula (I). This application further provides a method for preparing a drug for targeted protein degradation with such compound as an intermediate.

A compound of the following formula

##STR00001##

capable of binding to a tripartite motif (TRIM) protein E3 ubiquitin ligase (TRIM21). This application also provides a method for treating a disease associated with abnormal cell proliferation with the compound of formula (I). This application further provides a method for preparing a drug for targeted protein degradation with such compound as an intermediate.

The current invention describes a high-throughput catalytic process for the production of diesel fuel from domestic agricultural products, furfuraldehyde and plant fatty acids. In the present process, reacting medium and long chain fatty anhydrides (such as capric, caprylic, lauric and palmitic) with furfuraldehyde by a Perkin condensation produces 2-n-alkenylfurans. In a second step, the 2-n-alkenylfurans are hydrogenated to form 2-n-alkyltetrahydrofurans. Basic fuel property testing (melting point, density, kinematic viscosity, derived cetane number and calorific value) of the 2-n-alkyltetrahydrofurans indicates they are potentially useful as fuels for diesel engines. One mixture composed of 2-octyl- and 2-decyltetrahydrofuran had the best combination of fuel properties including a low melting point (39 C.), high cetane number (63.1), high flash point (98.2 C.) and low viscosity (2.26 mm2/sec, 40 C.) which compares favorably with specifications for diesel #2 and biodiesel.

The current invention describes a high-throughput catalytic process for the production of diesel fuel from domestic agricultural products, furfuraldehyde and plant fatty acids. In the present process, reacting medium and long chain fatty anhydrides (such as capric, caprylic, lauric and palmitic) with furfuraldehyde by a Perkin condensation produces 2-n-alkenylfurans. In a second step, the 2-n-alkenylfurans are hydrogenated to form 2-n-alkyltetrahydrofurans. Basic fuel property testing (melting point, density, kinematic viscosity, derived cetane number and calorific value) of the 2-n-alkyltetrahydrofurans indicates they are potentially useful as fuels for diesel engines. One mixture composed of 2-octyl- and 2-decyltetrahydrofuran had the best combination of fuel properties including a low melting point (39 C.), high cetane number (63.1), high flash point (98.2 C.) and low viscosity (2.26 mm2/sec, 40 C.) which compares favorably with specifications for diesel #2 and biodiesel.