Disclosed are compounds, for example, compounds of formula I,

##STR00001##

wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

Disclosed are compounds, for example, compounds of formula I, ##STR00001##
wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.

Disclosed are compounds, for example, compounds of formula I, ##STR00001##
wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.

A furan-based surfactant comprising a beta sulphonate head group, a furan and a C10-20 hydrophobic group which is either attached directly to the furan or by way of a linker. A laundry composition or a hand dish wash cleaning composition comprising said surfactant.

A furan-based surfactant comprising a beta sulphonate head group, a furan and a C10-20 hydrophobic group which is either attached directly to the furan or by way of a linker. A laundry composition or a hand dish wash cleaning composition comprising said surfactant.

Disulphide compounds of Formula (I) where Y is sulphuryl or sulphinyl Z is phenyl or substituted phenyl and the other variables are as defined in the claims; pharmaceutical compositions comprising these compounds and methods for making these compounds. These compounds are useful in therapeutic methods for treating microbial infection, inflammation and reducing the formation of blood clots and have non-therapeutic use as antimicrobial agents, anti-inflammatory agents and as anti-thrombotic agents.

##STR00001##

Disulphide compounds of Formula (I) where Y is sulphuryl or sulphinyl Z is phenyl or substituted phenyl and the other variables are as defined in the claims; pharmaceutical compositions comprising these compounds and methods for making these compounds. These compounds are useful in therapeutic methods for treating microbial infection, inflammation and reducing the formation of blood clots and have non-therapeutic use as antimicrobial agents, anti-inflammatory agents and as anti-thrombotic agents.

##STR00001##

Disclosed are compounds, for example, compounds of formula I, ##STR00001##
wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.