The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

The disclosure includes a method of using a biomass extraction and centrifugation system to extract and centrifuge biomass. In some embodiments, the method comprises loading a first portion of biomass into a vessel and loading a first portion of solvent into the vessel, and holding the first portion of biomass and the first portion of solvent in the vessel for a predetermined amount of time, whereby the first portion of biomass and the first portion of solvent define a first slurry of a first cycle. Accordingly, in some embodiments, the method comprises extracting at least a portion of a biomass extraction from the first slurry, and separating, via a centrifuge, the first slurry into a first extract discharge and a first waste discharge.

The disclosure includes a method of using a biomass extraction and centrifugation system to extract and centrifuge biomass. In some embodiments, the method comprises loading a first portion of biomass into a vessel and loading a first portion of solvent into the vessel, and holding the first portion of biomass and the first portion of solvent in the vessel for a predetermined amount of time, whereby the first portion of biomass and the first portion of solvent define a first slurry of a first cycle. Accordingly, in some embodiments, the method comprises extracting at least a portion of a biomass extraction from the first slurry, and separating, via a centrifuge, the first slurry into a first extract discharge and a first waste discharge.

The disclosure includes a method of using a biomass extraction and centrifugation system to extract and centrifuge biomass. In some embodiments, the method comprises loading a first portion of biomass into a vessel and loading a first portion of solvent into the vessel, and holding the first portion of biomass and the first portion of solvent in the vessel for a predetermined amount of time, whereby the first portion of biomass and the first portion of solvent define a first slurry of a first cycle. Accordingly, in some embodiments, the method comprises extracting at least a portion of a biomass extraction from the first slurry, and separating, via a centrifuge, the first slurry into a first extract discharge and a first waste discharge.

The disclosure includes a method of using a biomass extraction and centrifugation system to extract and centrifuge biomass. In some embodiments, the method comprises loading a first portion of biomass into a vessel and loading a first portion of solvent into the vessel, and holding the first portion of biomass and the first portion of solvent in the vessel for a predetermined amount of time, whereby the first portion of biomass and the first portion of solvent define a first slurry of a first cycle. Accordingly, in some embodiments, the method comprises extracting at least a portion of a biomass extraction from the first slurry, and separating, via a centrifuge, the first slurry into a first extract discharge and a first waste discharge.

A method for the extraction of natural ethyl maltol from passionflower plants is described. The plant material is extracted with a methanol based solvent and the natural ethyl maltol is recovered by column purification using a size exclusion purification column.

A method for the extraction of natural ethyl maltol from passionflower plants is described. The plant material is extracted with a methanol based solvent and the natural ethyl maltol is recovered by column purification using a size exclusion purification column.

Compounds of formula (I), wherein R.sub.1 is as defined in the claims, exhibit COMT enzyme inhibiting activity and are thus useful as COMT inhibitors. Methods of treatment and pharmaceutical dosage forms are also disclosed.

Compounds of formula (I), wherein R.sub.1 is as defined in the claims, exhibit COMT enzyme inhibiting activity and are thus useful as COMT inhibitors. Methods of treatment and pharmaceutical dosage forms are also disclosed.

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.