Method and system for a non-invasive assessment of a relation between an intracranial pressure and an intraocular pressure. The method comprising the steps of recording a plurality of images of a retina part of an eye of a person, identifying at least one vein, determining a first plurality of characteristic vein diameters for the identified vein at a first vein location, determining whether the at least one vein has experienced a vein collapse during the first time period, and determining a relation between intraocular pressure and intracranial pressure during the first time period.

Embodiments of the invention are directed towards systems, methods and computer program products for providing improved eye tests. Such tests improve upon current eye tests, such as visual field tests, by incorporating virtual reality, software mediated guidance to the patient or practitioner such that more accurate results of the eye tests are obtained. Furthermore, through the use of one or more trained machine learning or predictive analytic systems, multiple signals obtained from sensors of a testing apparatus are evaluated to ensure that the eye test results are less error-prone and provide a more consistent evaluation of a user's vision status. As it will be appreciated, such error reduction and user guidance systems represent technological improvements in eye tests and utilize non-routine and non-conventional approaches to the improvement and reliability of eye tests.

Intraocular physiological sensor implants include a physiological sensor, and a housing comprising a faceplate. The physiological sensor is integrated with the faceplate. The physiological sensor typically comprises an intraocular pressure sensor, such as a capacitive pressure sensor that may further include a flexible diaphragm electrode spaced apart from a counter electrode. The intraocular pressure sensor detects intraocular pressure, to identify patient conditions such as glaucoma.

Provided herein are systems and methods to measure the intraocular pressure, ocular tissue geometry and the biomechanical properties of an ocular tissue, such as an eye-globe or cornea, in one instrument. The system is an optical coherence tomography subsystem and an applanation tonometer subsystem housed as one instrument and interfaced with a computer for at least data processing and image display. The system utilizes an air-puff and a focused micro air-pulse to induce deformation and applanation and displacement in the ocular tissue. Pressure profiles of the air puff with applanation times are utilized to measure intraocular pressure. Temporal profiles of displacement and/or spatio-temporal profiles of a displacement-generated elastic wave are analyzed to calculate biomechanical properties.

Apparatus and methods are described including illumination equipment (300) configured to direct light into an eye of a subject. An optical device (100) is placed inside the subjects eye, the optical device including a Fabry Perot interferometer (106) comprising at least two mirrors (162, 164), the Fabry Perot interferometer (106) being configured such that a distance between the mirrors (162, 164) varies as an intraocular parameter of the subjects eye varies. A retroreflector (140) is configured such that light that is transmitted through the Fabry Perot interferometer (106) is automatically reflected out of the subjects eye. Readout equipment (400) is configured to detect the light that is reflected out of the subjects eye. Other applications are also described.

Apparatus and methods are described including illumination equipment (300) configured to direct light into an eye of a subject. An optical device (100) is placed inside the subjects eye, the optical device including a Fabry Perot interferometer (106) comprising at least two mirrors (162, 164), the Fabry Perot interferometer (106) being configured such that a distance between the mirrors (162, 164) varies as an intraocular parameter of the subjects eye varies. A retroreflector (140) is configured such that light that is transmitted through the Fabry Perot interferometer (106) is automatically reflected out of the subjects eye. Readout equipment (400) is configured to detect the light that is reflected out of the subjects eye. Other applications are also described.

The method for estimating the fluid state of a liquid of the present invention includes a step (a) of applying heat to the liquid, a step (b) of acquiring a temperature distribution of the liquid to which the heat is applied, and a step (c) of estimating the fluid state of the liquid based on the acquired temperature distribution. The system for estimating the fluid state of a liquid of the present invention includes a heating means (1) that applies heat to the liquid, a temperature distribution acquisition means (2) that acquires a temperature distribution of the liquid to which the heat is applied, and an estimation means (3) that estimates the fluid state of the liquid based on the acquired temperature distribution. According to such method and system for estimating the fluid state of a liquid, the flow of the liquid can be estimated non-invasively.

The method for estimating the fluid state of a liquid of the present invention includes a step (a) of applying heat to the liquid, a step (b) of acquiring a temperature distribution of the liquid to which the heat is applied, and a step (c) of estimating the fluid state of the liquid based on the acquired temperature distribution. The system for estimating the fluid state of a liquid of the present invention includes a heating means (1) that applies heat to the liquid, a temperature distribution acquisition means (2) that acquires a temperature distribution of the liquid to which the heat is applied, and an estimation means (3) that estimates the fluid state of the liquid based on the acquired temperature distribution. According to such method and system for estimating the fluid state of a liquid, the flow of the liquid can be estimated non-invasively.

A device for directly detecting pressure variations of a fluid within a body cavity is provided. The device has a pressure transducer, a pressure transmission device extending between a distal tip suitable for partial insertion into the body cavity and a proximal port in direct contact with a sensing surface of the pressure transducer. The distal tip forms an access port that places the pressure transducer outside the body cavity into direct fluid communication with the inside of the body cavity. The pressure transmission device has, between the distal tip and the proximal port, a flexible cannula having a length sufficient to allow anchoring of an intermediate stretch of the flexible cannula and/or the pressure transducer to an anchoring zone distant from the body cavity.

A device for directly detecting pressure variations of a fluid within a body cavity is provided. The device has a pressure transducer, a pressure transmission device extending between a distal tip suitable for partial insertion into the body cavity and a proximal port in direct contact with a sensing surface of the pressure transducer. The distal tip forms an access port that places the pressure transducer outside the body cavity into direct fluid communication with the inside of the body cavity. The pressure transmission device has, between the distal tip and the proximal port, a flexible cannula having a length sufficient to allow anchoring of an intermediate stretch of the flexible cannula and/or the pressure transducer to an anchoring zone distant from the body cavity.