Patent classifications
C07D473/30
Compounds targeting PRMT5
Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
Compounds targeting PRMT5
Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
Caffeine inhibitors of MTHFD2 and uses thereof
The present invention provides compounds, compositions thereof, and methods of using the same.
Caffeine inhibitors of MTHFD2 and uses thereof
The present invention provides compounds, compositions thereof, and methods of using the same.
COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE
Disclosed are compounds and compositions for inhibiting the expression of a pattern recognition receptor (e.g., STING), and methods of use thereof.
SALICYL-ADENOSINEMONOSULFAMATE ANALOGS AND USES THEREOF
Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts or tautomers thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment and/or prevention of an infectious disease (e.g., bacterial infection (e.g., Mycobacterium infection (e.g., tuberculosis)). (I)
##STR00001##
SALICYL-ADENOSINEMONOSULFAMATE ANALOGS AND USES THEREOF
Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts or tautomers thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment and/or prevention of an infectious disease (e.g., bacterial infection (e.g., Mycobacterium infection (e.g., tuberculosis)). (I)
##STR00001##
Substituted piperidines as inhibitors of ubiquitin specific protease 7
Compounds of formula (I): ##STR00001##
wherein R.sub.1, R.sub.2, R.sub.3, B, W, Z, m and n are as defined in the description.
Compound used as autophagy regulator, and preparation method therefor and uses thereof
It is related to compounds used as autophagy modulators and a method for preparing and using the same, specifically providing a compound of general formula (I), or pharmaceutically acceptable salts thereof, which is a type of autophagy modulators, particularly mammalian ATG8 homologues modulators. ##STR00001##
Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof
The present invention relates to a compound having the following formula, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, preparation method thereof, pharmaceutical composition comprising the same and use of the compound in the manufacture of a medicament for preventing or treating tumor, wherein the substituents are as defined in the specification. ##STR00001##