Reaction products and methods for making and using such reaction products are provided. For example, a reaction product comprising an adduct formed from urea, formaldehyde, and a urease inhibitor is described, which can be provided in various forms. For example, such a reaction product can be in the form of a solid or solution. Such a reaction product can also be combined with one or more additional components, including but not limited to, additional urease inhibitor and/or a nitrogen-based fertilizer composition.

The present invention relates to chiral phosphoramidimidates, their salts and metal complexes as well as derivatives thereof and their use as catalysts.

The present invention relates to chiral phosphoramidimidates, their salts and metal complexes as well as derivatives thereof and their use as catalysts.

An inhibitor composition contains alkyl thiophosphoric triamide (or a mixture of alkyl thiophosphoric triamide and dicyandiamide), dissolved in a liquid medium comprising at least one organic solvent, at least one amine stabilizer and, optionally, at least one dye and/or at least one odor masking agent, is useful in making fertilizer compositions and in a method of fertilizing target plants.

Compositions include dicyandiamide (DCD), N—(N-butyl) Thiophosphoric Triamide (NBPT), and styrene-maleic anhydride copolymer in a solution. Agricultural fertilizer compositions contain the DCD, NBPT and styrene-maleic anhydride copolymer composition in combination with a fertilizer.

Oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.

An improved solvent system for the formulation and application of N-alkyl thiophosphoric triamide urease inhibitors. These formulations provide safety and performance benefits relative to existing alternatives and enable storage, transport and subsequent coating or blending with urea based or organic based fertilizers. These formulations are comprised primarily of environmentally friendly aprotic and protic solvents (particularly dimethyl sulfoxide and alcohols/polyols) to stabilize the urease inhibitor.

An improved solvent system for the formulation and application of N-alkyl thiophosphoric triamide urease inhibitors. These formulations provide safety and performance benefits relative to existing alternatives and enable storage, transport and subsequent coating or blending with urea based or organic based fertilizers. These formulations are comprised primarily of environmentally friendly aprotic and protic solvents (particularly dimethyl sulfoxide and alcohols/polyols) to stabilize the urease inhibitor.

The invention describes membrane permeable creatine phosphate analog prodrugs, pharmaceutical compositions comprising membrane permeable creatine phosphate analog prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine phosphate analog prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine phosphate analog prodrugs or pharmaceutical compositions thereof.

Method for obtaining a fertilizer composition comprising (iii) at least one urea-containing fertilizer (1); and (iv) at least one (thio)phosphoric acid triamide (2) according to general formula (I) wherein X.sup.1 is O or S; R.sup.1 is C.sub.1-C.sub.20-alkyl, C.sub.3-C.sub.20-cycloalkyl, C.sub.6-C.sub.20-aryl, C.sub.6-C.sub.20-aryl-C.sub.1-C.sub.4-alkyl, or C.sub.1-C.sub.6-(di)alylaminocarbonyl; R.sup.2 is H, C.sub.1-C.sub.20-alkyl, C.sub.3-C.sub.20-cycloalkyl, C.sub.6-C.sub.20-aryl, C.sub.6-C.sub.20-aryl-C.sub.1-C.sub.4-alkyl, or C.sub.1-C.sub.6-(di)alkylaminocarbonyl; or R.sup.1 and R.sup.2 together with the nitrogen atom linking them define a 5- or 6-membered saturated or unsaturated heterocyclic radical, which optionally comprises 1 or 2 further heteroatoms selected from the group consisting of N, O, and S; and R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are independently of each other selected from the group consisting of H and C.sub.1-C.sub.4-alkyl; comprising the steps: a) providing a solid and/or liquid premix (P) wherein the premix (P) comprises at least one urea-containing fertilizer (1) and at least one (thio)phosphoric acid triamide (2) in a weight ratio of 1:6 to 400:1 based on the total weight of all urea-containing fertilizers (1) and of all (thio)phosphoric acid triamides (2), wherein at least 85 wt % of the premix (P) (a1) is not a melt; and (a2) is not obtained via melting of any of the at least one urea-containing fertilizer (1) or melting of any of the at least one (thio)phosphoric acid triamide (2); and (a3) is not obtained via dissolving or mixing the at least one (thio)phosphoric acid tri-amide (2) in/with a solvent (S) having a boiling point of less than 100° C., and b) adding the premix (P) to a melt (Q) comprising urea-containing fertilizer (1) by forming a mixture (M) n comprising the at least one urea-containing fertilizer (1) and the at least one (thio)phosphoric acid triamide (2), wherein the residence time of the thus formed mixture (M) before granulation is adjusted such that the at least one (thio)phosphoric acid tri-amide (2) is not or almost not decomposed in the mixture (M); and c) forming solid fertilizer granules by use of the mixture (M) comprising the at least one urea-containing fertilizer (1) and the at least one (thio)phosphoric acid triamide (2).

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