Patent classifications
C07F9/6515
HBED-bisphosphonates, radiometal conjugates and their use as theranostic agents
The present invention relates to compounds according to Formula I or Formula II, which are potential bone imaging agents. Certain compounds labeled with .sup.68Ga displayed excellent bone uptake and retention. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I or Formula II or a pharmaceutically acceptable salt thereof. ##STR00001##
HBED-bisphosphonates, radiometal conjugates and their use as theranostic agents
The present invention relates to compounds according to Formula I or Formula II, which are potential bone imaging agents. Certain compounds labeled with .sup.68Ga displayed excellent bone uptake and retention. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I or Formula II or a pharmaceutically acceptable salt thereof. ##STR00001##
Chelated PSMA Inhibitors
Compounds as defined herein are provided which are useful in (1) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable diluent; and (3) methods for imaging prostate cancer cells.
##STR00001##
Chelated PSMA Inhibitors
Compounds as defined herein are provided which are useful in (1) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable diluent; and (3) methods for imaging prostate cancer cells.
##STR00001##
Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C- functionalized derivatives thereof
A compound with formula (V) ##STR00001##
the synthesis method for compound (V), and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I) ##STR00002##
Also, metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.
Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C- functionalized derivatives thereof
A compound with formula (V) ##STR00001##
the synthesis method for compound (V), and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I) ##STR00002##
Also, metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.
Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof
The present invention embodiments relate to a compound with formula (V) ##STR00001## The invention also relates in certain embodiments to the synthesis method for compound (V) and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I) ##STR00002## The invention also relates in certain embodiments to metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.
Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof
The present invention embodiments relate to a compound with formula (V) ##STR00001## The invention also relates in certain embodiments to the synthesis method for compound (V) and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I) ##STR00002## The invention also relates in certain embodiments to metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.
Chelated PSMA inhibitors
Compounds as defined herein are provided which are useful in (1) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable diluent; and (3) methods for imaging prostate cancer cells. ##STR00001##
Chelated PSMA inhibitors
Compounds as defined herein are provided which are useful in (1) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable diluent; and (3) methods for imaging prostate cancer cells. ##STR00001##