Near-infrared activatable fluorescent small molecules for the photodynamic treatment of cancer are provided. Methods of treatment include contacting a plurality of cells of the cancer with a near-infrared activatable fluorescent small molecule and directing a near-IR light to the molecule for an amount of time sufficient to induce release of the active platinum species and a reactive oxygen species.

Provided is 2-(4-diethylamino)butylmalonic acid-(1R,2R)-(−)-1,2-cyclohexanediamine platinum(II) phosphate having high solubility, low hygroscopicity, and high stability and being suitable for preparing into various antitumor drug preparations. Also provided is a preparation method for amorphous 2-(4-diethylamino)butylmalonic acid-(1R,2R-)-1,2-cyclohexanediamine platinum(II) phosphate. The method is simple to operate and is suitable for industrial implementation.

The present disclosure relates platinum(IV) and texaphyrin linked conjugates and compositions comprising a texaphyrin and a platinum(IV) agent. The present disclosure also provides pharmaceutical compositions of the conjugates and compositions. Also, provided herein are methods of using the instant compounds in the treatment of cancer such as a platinum resistant cancer.

An organogold nonlinear optical chromophore includes gold complexed with a fluorophore optionally substituted an organophosphine ligand or an N-heterocyclic carbene ligand.

The current invention relates to series of co-crystals of platinum analogues and their pharmaceutical use. The co-crystals of the subject invention may be used in the treatment or prevention of cancers and virus infections.

Pt-DPEphos-iodine complex and Pt-DPEphos-bromine complex, and use thereof for catalysis of a hydroformylation reaction.

Pt-xanthene-iodine complex and Pt-xanthene-bromine complex, and use thereof for catalysis of a hydroformylation reaction.

Pt-biphenyl-iodine complex and Pt-biphenyl-bromine complex, and the use thereof for catalysis of a hydroformylation reaction.

Pt-thixantphos-iodine complex and Pt-thixantphos-bromine complex, and the use thereof for catalysis of a hydroformylation reaction.

Pt-xanthene-bromine complex, and use thereof for catalysis of a hydroformylation reaction.