Patent classifications
C07H15/06
Method of preparation of alpha galactosyl ceramides compounds
The present invention relates to a method of preparation of -galactosyl ceramides compounds of formula (I): ##STR00001##
comprising a step a) of glycosylation of a compound of formula (II): ##STR00002##
with a compound of formula (III): ##STR00003##
Method for producing an isolated monoclonal antibody specifically binding to a glycolipid antigen of <i>mycoplasma pneumoniae</i>
The present invention provides a novel glyceroglycolipid produced by Mycoplasma pneumoniae. The glyceroglycolipid can be used as a diagnostic marker for a disease caused by Mycoplasma pneumoniae.
Method for producing an isolated monoclonal antibody specifically binding to a glycolipid antigen of <i>mycoplasma pneumoniae</i>
The present invention provides a novel glyceroglycolipid produced by Mycoplasma pneumoniae. The glyceroglycolipid can be used as a diagnostic marker for a disease caused by Mycoplasma pneumoniae.
Chemical synthesis method of <i>Plesiomonas shigelloides </i>serotype O51 O-antigen oligosaccharide
The present disclosure discloses the chemical synthesis method of the Plesiomonas shigelloides serotype O51 O-antigen oligosaccharide, belonging to the field of chemistry. Source-abundant D-glucose, L-fucose, D-glucosamine and the like are used as raw materials to prepare three glycosylation building blocks, the synthetic route composed of 11 reaction modules is designed, and through the optimization of protecting group and the optimization of the time of introducing functional group, the preparation of the target oligosaccharide chain is successfully achieved. The oligosaccharide chain prepared in the present disclosure has the advantages of cheap and easy-to-get raw materials, and simple and easy-to-repeat preparation method. The present disclosure will have good application prospects in the aspects of development of new drugs and vaccines of Plesiomonas shigelloides, and the like.
Chemical synthesis method of <i>Plesiomonas shigelloides </i>serotype O51 O-antigen oligosaccharide
The present disclosure discloses the chemical synthesis method of the Plesiomonas shigelloides serotype O51 O-antigen oligosaccharide, belonging to the field of chemistry. Source-abundant D-glucose, L-fucose, D-glucosamine and the like are used as raw materials to prepare three glycosylation building blocks, the synthetic route composed of 11 reaction modules is designed, and through the optimization of protecting group and the optimization of the time of introducing functional group, the preparation of the target oligosaccharide chain is successfully achieved. The oligosaccharide chain prepared in the present disclosure has the advantages of cheap and easy-to-get raw materials, and simple and easy-to-repeat preparation method. The present disclosure will have good application prospects in the aspects of development of new drugs and vaccines of Plesiomonas shigelloides, and the like.
MOLECULES FROM SEAWEEDS WITH ANTI-CANCER ACTIVITY
The present invention provides purified compounds extracted from seaweeds having the formula (I):
##STR00001##
wherein R.sup.1 and R.sup.2 is each independently H or a fatty acid and their use for inhibiting the growth of cancer cells.
MOLECULES FROM SEAWEEDS WITH ANTI-CANCER ACTIVITY
The present invention provides purified compounds extracted from seaweeds having the formula (I):
##STR00001##
wherein R.sup.1 and R.sup.2 is each independently H or a fatty acid and their use for inhibiting the growth of cancer cells.
Sophorolipid compound and composition comprising same
The subject invention provides a novel SL that is widely applicable to various fields including food or beverages, cosmetics, pharmaceuticals, and quasi-drugs. A sophorolipid compound represented by Formula (I) below: ##STR00001##
(in Formula (I), R.sub.1 represents H or a methyl group; R.sub.3 and R.sub.4 each represents H or an acetyl group; one of five R.sub.5 is a saturated or unsaturated fatty acid residue that may have an OH group, and the remaining four R.sub.5 are H; R.sub.2 represents a C.sub.9-18 alkylene group, or C.sub.9-18 alkenylene group having 1 to 3 double bonds; R.sub.6 represents hydroxy, or may form a single bond together with one of five R.sub.7 in the compound represented by Formula (II) below) ##STR00002##
(in Formula (II), R.sub.1 represents H or methyl group; R.sub.3 and R.sub.4 each represents H or an acetyl group; R.sub.2 represents a C.sub.9-18 alkylene group, or C.sub.9-18 alkenylene group having 1 to 3 double bonds).
Sophorolipid compound and composition comprising same
The subject invention provides a novel SL that is widely applicable to various fields including food or beverages, cosmetics, pharmaceuticals, and quasi-drugs. A sophorolipid compound represented by Formula (I) below: ##STR00001##
(in Formula (I), R.sub.1 represents H or a methyl group; R.sub.3 and R.sub.4 each represents H or an acetyl group; one of five R.sub.5 is a saturated or unsaturated fatty acid residue that may have an OH group, and the remaining four R.sub.5 are H; R.sub.2 represents a C.sub.9-18 alkylene group, or C.sub.9-18 alkenylene group having 1 to 3 double bonds; R.sub.6 represents hydroxy, or may form a single bond together with one of five R.sub.7 in the compound represented by Formula (II) below) ##STR00002##
(in Formula (II), R.sub.1 represents H or methyl group; R.sub.3 and R.sub.4 each represents H or an acetyl group; R.sub.2 represents a C.sub.9-18 alkylene group, or C.sub.9-18 alkenylene group having 1 to 3 double bonds).
Enhancement of cell cryopreservation with glycolipids
Living cellular material may be preserved by incubating the cellular material in a culture medium containing at least one glycolipid, and then subjecting the cellular material to a preservation protocol.