Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands are disclosed. For example, heterobifunctional inhibitors of E-selectin and galectin-3 are described and pharmaceutical compositions comprising at least one such agent is described.

Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands are disclosed. For example, heterobifunctional inhibitors of E-selectin and galectin-3 are described and pharmaceutical compositions comprising at least one such agent is described.

A stabilized amorphous form of a compound of formula I as well as compositions for oral administration including the compound of formula I in a therapeutically effective amount. Also, methods for treatment of a disease or disorder in which therapeutically effective amount of a composition including a compound of formula I is administered to a subject in need thereof.

A stabilized amorphous form of a compound of formula I as well as compositions for oral administration including the compound of formula I in a therapeutically effective amount. Also, methods for treatment of a disease or disorder in which therapeutically effective amount of a composition including a compound of formula I is administered to a subject in need thereof.

Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of galectin-3 to ligands are disclosed. For example, inhibitors of galectin-3 are described and pharmaceutical compositions comprising at least one such agent is described.

Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of galectin-3 to ligands are disclosed. For example, inhibitors of galectin-3 are described and pharmaceutical compositions comprising at least one such agent is described.

The invention describes novel conjugates of formula (I) of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein allowing a reversible release of the pharmaceutical agent depending on the glucose concentration.

The invention describes novel conjugates of formula (I) of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein allowing a reversible release of the pharmaceutical agent depending on the glucose concentration.

A saccharide derivative represented by Chemical Formula (1) or (2), or a salt thereof, includes units of a monosaccharide linked to each other in a chainlike or cyclic manner through glycosidic bonding and has antimicrobial action. In the formulae, R.sup.1 represents an amino-containing structure; and n represents an integer of 3 or more. A saccharide derivative represented by Chemical Formula (5) or (6), or a salt thereof, includes units of a monosaccharide linked to each other in a chainlike or cyclic manner through glycosidic bonding and has antimicrobial activity enhancing action. In the formulae, R.sup.3 represents an amino-containing structure; R.sup.4 is selected from acetyl and propanoyl; and n represents an integer of 3 or more.

##STR00001##

A saccharide derivative represented by Chemical Formula (1) or (2), or a salt thereof, includes units of a monosaccharide linked to each other in a chainlike or cyclic manner through glycosidic bonding and has antimicrobial action. In the formulae, R.sup.1 represents an amino-containing structure; and n represents an integer of 3 or more. A saccharide derivative represented by Chemical Formula (5) or (6), or a salt thereof, includes units of a monosaccharide linked to each other in a chainlike or cyclic manner through glycosidic bonding and has antimicrobial activity enhancing action. In the formulae, R.sup.3 represents an amino-containing structure; R.sup.4 is selected from acetyl and propanoyl; and n represents an integer of 3 or more.

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