Disclosed herein are methods for making a poptoid using green solvents such as ethyl acetate, DMSO and/or mixtures thereof. Methods using an acylation solvent that is DMSO or EIOAc or mixtures thereof as well as methods using an acylation wash solvent comprising DMSO wherein the DMSO is greater than 30% v/v are described.

The present invention relates to an improved process for the preparation of Liraglutide.

The present invention further related an improved process for the preparation of substantially pure material having a purity of greater than or equal to 99.5% by HPLC, wherein the process involves hybrid technology of both manual and microwave to produce Liraglutide.

Provided herein is an environmentally friendly method of solid-phase peptide synthesis (SPPS), wherein the method employs isopropyl alcohol (IPA) as the major solvent or co-solvent in the synthesis steps of deprotection, washing, and coupling. The presently disclosed methods employ IPA in place of traditional solvents such as N,N-dimethylformamide (DMF) and dichloromethane (DCM).