The present invention relates to peptides, and amino acid and peptide conjugates, methods for making amino acid and peptide conjugates, conjugates produced by the methods, pharmaceutical compositions comprising the peptides and conjugates, methods of eliciting immune responses in a subject and methods of vaccinating a subject, uses of the peptides and conjugates for the same, and uses of the peptides and conjugates in the manufacture of medicaments for the same.

A multifunctional chemical agents comprising functional agents Fn1, Fn2 and linkers, for the linchpin directed (LDM), protein directed (PDPM) modifications of proteins, and Fn1 accelerated kinetic labeling by Fn2.

There is described herein use of a compound of formula (I) below to make cyclic peptides. ##STR00001##

The invention provides methods for generating human antibodies with the specificity of a reference antibody by replacement of portions of the V.sub.H and V.sub.L sequences of the reference antibody with sequences from human antibody repertoires. The invention also provides novel compositions comprising hybrid immunoglobulin variable domains containing a combination of frameworks (FRs) and CDRs from different antibody clones.

The present invention provides means and methods for equipping a polypeptide of interest at its C-terminus with a versatile adaptor amino acid that allows the functionalization of the polypeptide of interest.

Provided is a method for amidating a hydroxy ester compound at a high chemical selectivity. The amidation reaction method for a hydroxy ester compound comprises, in the presence of a catalyst containing a compound of a transition metal of the group 4 or group 5 in the periodic table, reacting at least one kind of hydroxy ester compound selected from the group consisting of an -hydroxy ester compound, a -hydroxy ester compound, a -hydroxy ester compound and a -hydroxy ester compound with an amino compound so as to amidate an ester group having a hydroxyl group at the -, -, - or -position of the hydroxy ester compound.

The present invention relates to a method of producing an immunoligand/payload conjugate, which method encompasses conjugating a payload to an immunoligand by means of a sequence-specific transpeptidase, or a catalytic domain thereof.

The present disclosure relates to a polypeptide exhibiting granulocyte-colony stimulating factor activity. The polypeptide comprises at least one non-native cysteine residue at a site selected from the group consisting of T.sub.1CP.sub.2 (SEQ ID NO: 25), P.sub.2CL.sub.3 (SEQ ID NO: 26), L.sub.3CG.sub.4 (SEQ ID NO: 27), G.sub.4CP.sub.5 (SEQ ID NO: 28), P5CA.sub.6 (SEQ ID NO: 29), A.sub.6CS.sub.7 (SEQ ID NO: 30), S.sub.96CP.sub.97 (SEQ ID NO: 31), P.sub.97CE.sub.98 (SEQ ID NO: 32), L.sub.99CG.sub.100 (SEQ ID NO: 33), P.sub.101CT.sub.102 (SEQ ID NO: 34), E.sub.122CE.sub.123 (SEQ ID NO: 35), L.sub.124CG.sub.125 (SEQ ID NO: 36), M.sub.126CA.sub.127 (SEQ ID NO: 37), P.sub.138CA.sub.139 (SEQ ID NO: 39), A.sub.143CF.sub.144 (SEQ ID NO: 40), R.sub.146CR.sub.147 (SEQ ID NO: 41), R.sub.169CH.sub.170 (SEQ ID NO: 42), H.sub.170CL.sub.171 (SEQ ID NO: 43), L.sub.171CA.sub.172 (SEQ ID NO: 44), A.sub.172CQ.sub.173 (SEQ ID NO: 45), and Q.sub.173CP.sub.174 (SEQ ID NO: 46) in an amino acid sequence having at least 90% sequence identity to sequence set forth in SEQ ID NO: 2.

The disclosure describes a recombinant immunoglobulin heavy chain comprising a sortase conjugation loop, methods for conjugating and/or labeling such recombinant immunoglobulin heavy chains by use of the enzyme sortase and to the conjugates/labeled products obtained via the method.

The present invention relates to the diagnosis and treatment of diseases expressing Fibronectin Extra Domain B (EDB) such as diseases characterized by tissue remodeling and/or angiogenesis, in particular cancerous diseases, such as head and neck, brain, colorectal, lung, prostate and breast cancer. More particularly, the invention concerns peptides targeting Fibronectin Extra Domain B.