Patent classifications
C07K5/1027
Solution phase synthesis of β-turn peptidomimetic cyclic salts
The present disclosure relates to methods of preparing and crystallizing -turn cyclic peptidomimetic salts of formula I: ##STR00001##
where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.10, X, Y and n are as defined in the specification. The present disclosure provides a more efficient route for preparing a crystalline form of a -turn cyclic peptidomimetic compounds and salts thereof.
SOLUTION PHASE SYNTHESIS AND CRYSTALLIZATION OF BETA-TURN PEPTIDOMIMETIC CYCLIC SALTS
The present disclosure relates to methods of preparing and crystallizing -turn cyclic peptidomimetic salts of formula I:
##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.10, X, Y and n are as defined in the specification.
The present disclosure provides a more efficient route for preparing a crystalline form of -turn cyclic peptidomimetic compounds and salts thereof.
Oligopeptide linker intermediate and preparation method thereof
The invention provides a new oligopeptide linker intermediate and a preparation method thereof. The preparation method of the oligopeptide intermediate is easily carried out under mild reaction conditions, and since almost no side reactions occur in the reaction, the method produces a high-purity product with fewer impurities and easy to be purified, achieving unexpected technical effects.