Patent classifications
C
CHEMISTRY; METALLURGY
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C07
ORGANIC CHEMISTRY
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C07K
PEPTIDES
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5/00
Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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C07K5/04
containing only normal peptide links
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C07K5/12
Cyclic peptides; with only normal peptide bonds in the ring
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C07K5/123

Cyclic peptides as ADAM protease inhibitors
09546198 · 2017-01-17 · ·

The invention relates to a method for inhibiting an ADAM protease, comprising inhibiting binding to an integrin-binding loop of a disintegrin domain in the ADAM protease. Also provided are cyclic peptides which inhibit binding to an integrin-binding loop of an ADAM protease, as well as associated pharmaceutical compositions, uses and methods of treatment.