The present invention pertains to a group of taxane-lipid-polysaccharide dual conjugates of the Formula I, a process for the preparation thereof, uses thereof, and pharmaceutical compositions comprising the same. The invention also relates to a series of intermediates for the preparation of taxane-lipid-polysaccharide dual conjugates, a process for their preparation, and their use as drug delivery vehicles.

##STR00001##

Interactions between aqueous fluids and clay-containing subterranean formations may be problematic due to issues associated with clay destabilization and migration. Functionalized dextrin compounds that are partially oxidized and bear at least one amine group at an oxidation site may promote clay stabilization for more effective treatment of a subterranean formation. Subterranean treatment methods may comprise: providing a clay stabilizing composition comprising an amine-functionalized dextrin compound, the amine-functionalized dextrin compound comprising 2 to about 20 glucose units linked together with α(1,4) glycosidic bonds, and a portion of the glucose units being oxidatively opened and functionalized with at least one amine group at a site of oxidative opening; introducing the clay stabilizing composition into a subterranean formation bearing a clay-containing mineral; and interacting the amine-functionalized dextrin compound with the clay-containing mineral to affect stabilization thereof.

Modified biopolymers, such as, charge-modified biopolymers, cross-linked biopolymers, and cross-linked, charge-modified biopolymers are provided along with methods of producing and using the same.

Disclosed is a preparation method of a starch-based hemostatic powder, comprising the following steps: (1) starch modification; (2) emulsification and crosslinking; (3) separation, purification, drying and sterilization. Provided is a starch-based hemostatic powder, which has a simple preparation process and a controllable cost. After being modified, raw material medical potato starch has a high degree of emulsification and crosslinking and a good and uniform spherical shape, and has a porous structure. Moreover, the product has good biocompatibility, low biological cytotoxicity, and obvious antibacterial effect; the product has a high liquid absorption ratio, and quickly forms a gel to cover the wound surface after liquid absorption, thus achieving a good hemostatic effect. The starch-based hemostatic powder is an excellent biomedical product, and can be used for clinical wound treatment, surgery to prevent organ adhesion, and bleeding from various wounds.

Modified biopolymers, such as, charge-modified biopolymers, cross-linked biopolymers, and cross-linked, charged modified biopolymers are provided along with methods of producing and using the same.

A leuco polymer comprising a polymeric carbohydrate and a leuco moiety. The polymeric carbohydrate and the leuco moiety are covalently bound. Methods of making the leuco polymer, laundry care compositions comprising the leuco polymer and methods of treating textiles with such laundry care compositions.

The present disclosure provides stable, low chloride paint detackifier compositions. Also disclosed are methods of making the paint detackifier compositions and methods of using the paint detackifier compositions. The detackifier may be made from cationized starch and sodium aluminate. The starch can be wheat starch, corn starch, tapioca starch, potato starch, rice starch, sweet potato starch, sago starch, mung bean starch, arrowroot starch, and any combination thereof.

Compositions and methods related to powdered hemostats that crosslink during and/or after application to a bleeding site are generally described.

Interactions between aqueous fluids and clay-containing subterranean formations may be problematic due to issues associated with clay destabilization and migration. Functionalized dextrin compounds that are partially oxidized and bear at least one amine group at an oxidation site may promote clay stabilization for more effective treatment of a subterranean formation. Subterranean treatment methods may comprise: providing a clay stabilizing composition comprising an amine-functionalized dextrin compound, the amine-functionalized dextrin compound comprising 2 to about 20 glucose units linked together with (1,4) glycosidic bonds, and a portion of the glucose units being oxidatively opened and functionalized with at least one amine group at a site of oxidative opening; introducing the clay stabilizing composition into a subterranean formation bearing a clay-containing mineral; and interacting the amine-functionalized dextrin compound with the clay-containing mineral to affect stabilization thereof.

The present disclosure provides stable, low chloride paint detackifier compositions. Also disclosed are methods of making the paint detackifier compositions and methods of using the paint detackifier compositions. The detakifier may be made from cationized starch and sodium aluminate. The starch can be wheat starch, corn starch, tapioca starch, potato starch, rice starch, sweet potato starch, sago starch, mung bean starch, arrowroot starch, and any combination thereof.