This invention relates to radiopaque polymers and to their use, particularly in the manufacture of medical devices and in methods of medical treatment, including therapeutic embolization. In particular embodiments the present disclosure relates to a hydrophilic polymer comprising pendent groups which a phenyl ring is substituted with one or more iodine groups and one or more non-iodine groups as described in more detail herein.

This invention relates to radiopaque polymers and to their use, particularly in the manufacture of medical devices and in methods of medical treatment, including therapeutic embolization. In particular embodiments the present disclosure relates to a hydrophilic polymer comprising pendent groups which a phenyl ring is substituted with one or more iodine groups and one or more non-iodine groups as described in more detail herein.

The present invention relates to novel nanoparticles using an anionic polymer, a preparation method thereof, a composition, and the like, and the present invention is used for a method of necrosing cancer cells by blocking major blood vessels that supply nutrients to cancer cells to induce an embolic effect, and thus may be used for the treatment of patients with cancer.

The present invention relates to novel nanoparticles using an anionic polymer, a preparation method thereof, a composition, and the like, and the present invention is used for a method of necrosing cancer cells by blocking major blood vessels that supply nutrients to cancer cells to induce an embolic effect, and thus may be used for the treatment of patients with cancer.

The present invention provides a laminate used in an image display device the laminate including an optically anisotropic layer, a light-absorbing anisotropic layer, a refractive index-adjusting layer, and an oxygen shielding layer in this order, where the light-absorbing anisotropic layer is formed of a composition containing dichroic azo coloring agent and liquid crystalline compounds, where the dichroic azo coloring agent compound is 10% to 30% by mass with respect to a mass of a total solid content of the light-absorbing anisotropic layer, a degree of alignment of the light-absorbing anisotropic layer is 0.92 or higher, the refractive index-adjusting layer is formed of a composition containing a crosslinkable group compound, and has an in-plane average refractive index of 1.55 to 1.70 (550 nm λ), and an angle formed by an in-plane slow axis of the optically anisotropic layer and an absorption axis of the light-absorbing anisotropic layer is 45°±10°.

The present invention provides a laminate used in an image display device the laminate including an optically anisotropic layer, a light-absorbing anisotropic layer, a refractive index-adjusting layer, and an oxygen shielding layer in this order, where the light-absorbing anisotropic layer is formed of a composition containing dichroic azo coloring agent and liquid crystalline compounds, where the dichroic azo coloring agent compound is 10% to 30% by mass with respect to a mass of a total solid content of the light-absorbing anisotropic layer, a degree of alignment of the light-absorbing anisotropic layer is 0.92 or higher, the refractive index-adjusting layer is formed of a composition containing a crosslinkable group compound, and has an in-plane average refractive index of 1.55 to 1.70 (550 nm λ), and an angle formed by an in-plane slow axis of the optically anisotropic layer and an absorption axis of the light-absorbing anisotropic layer is 45°±10°.

A method for manufacture of plasticized homopolymeric polyvinyl alcohol, the method comprising the steps of: introducing into a mixing reactor a polyvinyl alcohol polymer comprising polyvinyl alcohol or a blend thereof having a degree of hydrolysis in the range of 93 wt % to 98 wt %; wherein the mixing reactor comprises a blending chamber having a primary inlet, a primary outlet and at least two inter-engaging components extending between the primary inlet and primary outlet, the components being arranged to apply a shearing force to the polymer while the polymer is conveyed by the components from the inlet through a reaction zone to the outlet; one or more secondary inlets located downstream from the primary inlet for introducing reactants comprising a processing aid, a plasticizer and a reactive stabiliser stabilizer to the chamber to form a reaction mixture; wherein the plasticizer is selected from the group consisting of: sugar alcohols, diols, triols, polyols and mixtures thereof; wherein the reactive stabilizer is selected from the group consisting of: sodium stearate, potassium oleate, sodium benzoate, calcium stearate, stearic acid, dimethyl propionic acid, and mixtures thereof; wherein the blending chamber comprises a plurality of heated regions arranged so that the mixture is subjected to a temperature profile whereby the temperature increases from the inlet to the outlet; a secondary outlet located between the reaction zone and primary outlet arranged to allow removal of processing aid from the chamber; reacting the processing agent, plasticizer and polymer in the reaction zone to form plasticized polymer; and allowing the plasticized polymer to pass from the primary outlet.

A method for manufacture of plasticized homopolymeric polyvinyl alcohol, the method comprising the steps of: introducing into a mixing reactor a polyvinyl alcohol polymer comprising polyvinyl alcohol or a blend thereof having a degree of hydrolysis in the range of 93 wt % to 98 wt %; wherein the mixing reactor comprises a blending chamber having a primary inlet, a primary outlet and at least two inter-engaging components extending between the primary inlet and primary outlet, the components being arranged to apply a shearing force to the polymer while the polymer is conveyed by the components from the inlet through a reaction zone to the outlet; one or more secondary inlets located downstream from the primary inlet for introducing reactants comprising a processing aid, a plasticizer and a reactive stabiliser stabilizer to the chamber to form a reaction mixture; wherein the plasticizer is selected from the group consisting of: sugar alcohols, diols, triols, polyols and mixtures thereof; wherein the reactive stabilizer is selected from the group consisting of: sodium stearate, potassium oleate, sodium benzoate, calcium stearate, stearic acid, dimethyl propionic acid, and mixtures thereof; wherein the blending chamber comprises a plurality of heated regions arranged so that the mixture is subjected to a temperature profile whereby the temperature increases from the inlet to the outlet; a secondary outlet located between the reaction zone and primary outlet arranged to allow removal of processing aid from the chamber; reacting the processing agent, plasticizer and polymer in the reaction zone to form plasticized polymer; and allowing the plasticized polymer to pass from the primary outlet.

Water-soluble films, water-soluble unit dose articles, and related methods of making and using the same.

Water-soluble films, water-soluble unit dose articles, and related methods of making and using the same.