A method of preparing a fluorinated polycaprolactone membrane includes the following steps: (1) reacting a polycaprolactone with an aminoalcohol compound to prepare a hydroxyl-terminated polycaprolactone; (2) reacting the hydroxyl-terminated polycaprolactone with an anhydride to prepare a carboxyl-terminated polycaprolactone; (3) reacting an ethylene glycol bromoisobutyrate with a fluorinated acrylate to prepare a hydroxyl-terminated fluoro-acrylate polymer; (4) reacting the carboxyl-terminated polycaprolactone with the hydroxyl-terminated fluoro-acrylate polymer to prepare a fluorinated polycaprolactone; (5) at room temperature, dissolving the fluorinated polycaprolactone in an organic solvent to prepare a solution; then naturally drying the solution at room temperature to prepare the fluorinated polycaprolactone membrane.

Provided is a triblock copolymer comprising a poly(3-hydroxypropionate) block, and polylactide blocks bonded to both ends of the poly(3-hydroxypropionate) block. Also provided is a method for preparing a triblock copolymer by ring-opening polymerization of lactide monomers in the presence of a poly(3-hydroxypropionate) initiator having hydroxy groups at both ends.

The invention features adhesive devices for holding objects (e.g., bone fragments) fixed with respect to each other.

Provided is a lactic acid-based block copolymer which is biodegradable while having excellent mechanical properties.

The present invention relates to polymers, compositions thereof, and methods of producing polymers in general. Furthermore, the present invention relates to pharmaceutical compositions and uses of said polymers, compositions and pharmaceutical compositions. More particular, the present invention relates to polymers of jasmine lactone, where pendant groups of said polymers can readily be used for attaching functional moieties comprising active agents. Furthermore, the present invention relates to modified jasmine lactones that can readily be used in methods of producing polymers of the present invention. More particular, the invention relates to polymers from renewable monomers, which can be used in applications such as drug delivery and diagnosis, polymer-drug conjugates, medical devices, cosmetic products, polymers with marker unit, polymers usable as flame retardants, tissue engineering, coatings, paints, lubricants and biodegradable plastics.

The presently claimed invention relates to a dispersant containing oxyalkylenecarbonyl units and a process for its preparation. The presently claimed invention is also directed to the use of the dispersant in a coating composition or an ink composition.

The present invention concerns the use of PCL in preparing a block copolymer comprising at least one rigid block and at least one flexible block, for enhancing the sebum resistance of said block copolymer.

The present invention also provides a sebum-resistant block copolymer, characterized in that it comprises rigid blocks and flexible blocks comprising at least 50% by weight of PCL, based on the total weight of flexible blocks, which represents 100%; a process for synthesizing said copolymer; and also compositions and articles comprising a sebum-resistant copolymer of this kind.

The invention features adhesive devices for holding objects (e.g., bone fragments) fixed with respect to each other.

According to the present disclosure, a bioadhesive formulation is provided. The bioadhesive formulation comprises a polycaprolactone dendrimer having a dendrimer core and a plurality of polycaprolactone chains extending from the dendrimer core, wherein at least one of the polycaprolactone chains has an end which is covalently attached with a diazirine, and wherein the diazirine converts to a carbene or a diazoalkyl when a stimulant is applied to the bioadhesive formulation. Methods of forming the bioadhesive formulation are also provided. The bioadhesive could be used in (i) the prevention of thrombosis from tissue fixation and/or (ii) the relief of discomfort and/or pain during and/or after surgery. Preferably, the bioadhesive formulation further comprises a hygroscopic additive, an antithrombotic agent, and/or an anaesthetic agent.

The present invention relates to an amphiphilic block copolymer represented by formula I, a preparation method thereof, and a nanomicelle drug delivery system formed from the copolymer and a poorly soluble drug. The amphiphilic block copolymer includes a hydrophilic chain segment, a hydrophobic chain segment, and a linker for linking the hydrophilic chain segment to the hydrophobic chain segment. The linker contains an unsaturated structure, which can enhance the interaction between the poorly soluble drug and the copolymer to improve the drug loading ability and stability of the nanomicelle. The invention also relates to a nanomicelle drug-loading system, a preparation method thereof, and the use of the nanomicelle drug-loading system for preparing medicines for treating tumors, inflammation, diabetes, central nervous system diseases, cardiovascular diseases, and psychological disorders.

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